Renal disease in infective endocarditis in intravenous drug users: clinical characteristics and tubulo-interstitial damage


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Abstract

Aim. Clinical characteristics of renal disease infective endocarditis (IE) in intravenous drug users (IVDU). Methods. In 44 patients — IVDU with IE and 44 patients — non-IVDU with IE (control group) signs of renal disease were analysed: glomerular filtration rate (eGFR) was estimated according to MDRD formula; albuminuria, urinary concentration of α1-Microglobulin, urinary activity of γ-glutamyl-transferase (γGT) and lactate-dehydrogenase (LDH) were determined. Systemic markers of inflammation (serum C-reactive protein level, serum circulating immune complex level) were analysed. Results. IVDU with IE had higher proteinuria, more prominent hematuria, and lover levels of eGFR. 23% of IVDU with IE had nephrotic syndrome without hypercholesterolemia. IVDU with IE also demonstrated elevation of urinary activity of LDH. Signs of glomerular and tubule-interstitial damage correlated with systemic inflammatory response and Staphylococcus spp. as a causative agent of IE. Conclusion. Signs of renal disease (glomerular and tubulo-interstitial damage) are more prominent in intravenous drugs users with infective endocarditis.

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References

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