Interrelations between natriuresis, central hemodynamics parameters and plasma angiotensin II concentration


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Aim. Estimation of activity of renin-angiotensin-aldosterone system (Raas), changes of central hemodynamics parameters, fluid retention and natriuresis in salt-sensitive and salt-resistant patients on high- and low-salt diet. Methods. 103 patients, according to M.H. Weinberger test 56 of them salt-sensitive and 47 - salt-resistant, were included into the study. Determination of plasma level of angiotensin II (AT її), central hemodynamics parameters and bioimpedamsometry were performed twice: 1st time - after 5 days of low salt intake, 2nd - after end of high salt intake period. Total salt intake was assessed according to morning urine concentration of sodium and creatinine with use of t. Tanake formula. Results. Raas activity increased simultaneously with natriuresis increase in both hight and low sodium intake food regimen. In low sodium intake fluid retention was minimal or absent. In high salt intake period fluid retention was associated with decrease of natriuresis. Conclusion. Renin-angiotensin-aldosterone system activity, changes of central hemodynamics parameters, fluid retention and natriuresis are interrelated with food sodium intake in salt-sensitive and salt-resistant patients.

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