Biomarkers in assessment of renal involvement in patients with arterial hypertension
- Authors: Kraidashenko O.V1, Dolinnaya M.A1
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- Issue: No 3 (2014)
- Pages: 23-25
- Section: Articles
- URL: https://journals.eco-vector.com/2075-3594/article/view/262563
- ID: 262563
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Abstract
Aim. Assessment of association between biomarkers and parameters, characterizing tubulo-interstitial involvement in patients with chronic glomerulonephritis and arterial hypertension. Methods. 44 patients with arterial hypertension and 49 patients with chronic glomerulonephritis were included into the study. In all patients standard clinical and laboratory parameters were analyzed. In patients with chronic glomerulonephritis renal biopsy was performed. Serum and urine concentrations of neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) were determined by Elisa. Results. Correlations between morphological characteristics of renal damage and biomarkers levels in patients with chonic glomerulonephritis show serum and urine level of NGAL and serum level of IL-18 as an informative sign of tubulo-interstitial involvement in chronic glomerulonephritis. Despite absence of microalbuminuria absence, markers of tubulo-interstitial damage can be also found in patients with arterial hypertension. Conclusion. Biomarkers can be used for early diagnosis of tubulo-intestitial involvement in patients with chronic glomerulonephritis and arterial hypertension.
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