The role of leptin in the pathogenesis of malnutrition in chronic hemodialysis patients


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Abstract

Aim. To clarify the role of leptin in the development of malnutrition in chronic hemodialysis (HD) patients. Material and methods. The study sample consisted of 78 patients with end-stage renal disease treated with chronic HD, including 38 women and 40 men aged 52,2±і2,9 year. Nutritional status and body composition were assessed by integrated nutritional evaluation, caliper measurements, and bioimpedance analysis. The concentration of plasma leptin was determined by radioimmunoassay (Active Human Leptin Elisa, 10-231001, dsl, usa). The reference ranges were for women - 1,1-27,5 for men - 0,5-13,8 ng/ml. Results. The study results showed a significant reduction of the basic indicators of nutritional status in HD patients with hyperleptinemia. Conclusion. Hyperleptinemia may be an independent factor causing the development of malnutrition in chronic HD patients.

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References

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