Heart damage in patients with atypical hemolytic-uremic syndrome

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Abstract

The article presents five clinical cases of cardiac damage in patients with aGUS and review of the literature highlighting the main aspects of cardiovascular disease in these patients. It analyzes the main clinical manifestations and features of thrombotic myocardial microangiopathy. TMM is proposed to consider as a new cause of cardiorenal syndrome type 5.

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References

  1. Campistol J.M., Arias M., Ariceta G., Blasco M., Espinosa M., Grinyo J.M., Praga M., Torra R., Vilalta R., Rodriguez de Cordoba S. An update for atypical haemolytic uremic syndrome: diagnosis and treatment. A consensus document. Nefrologia. 2013; 33: 27-45.
  2. Noris M., Remuzzi G. Atypical hemolytic-uremic syndrome. N. Engl. J. Med. 2009; 361: 1676-1687.
  3. Лора Ш., Фремю-Бачи В. Атипичный ГУС. Нефрология. 2012; 16(2): 16-48.
  4. Kavanagh D., Goodship T. Genetics and complement in atypical HUS. Pediatr. Nephrol. 2010; 25: 2431-2442.
  5. Ruggenenti P., Noris M., Remuzzi G. Thrombotic microangiopathy, haemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. Kidney Int. 2001; 60: 831-846.
  6. Taylor C.M., Chua C., Howie A.J., Risdon R.A.; British Association for Paediatric Nephrology. Clinico-pathological findings in diarrhea-negative haemolytic uremic syndrome. Pediatr. Nephrol. 2004; 19: 419-425.
  7. Hofer J., Rosales A., Fisher C., Giner T. Extra-renal manifestations of complement-mediated thrombotic microangiopathies. Pediatr. Nephrol. 2014; 2: 97.
  8. Noris M., Remuzzi G. Cardiovascular complications in atypical haemolytic uraemic syndrome. Nat. Rev. Nephrol. 2014; 10(3): 174-180.
  9. Patschan D., Witzke O., Dührsen U., Erbel R., Philipp T., Herget-Rosenthal S. Acute myocardial infarction in thrombotic microangiopathies - clinical characteristics, risk factors and outcome. Nephrol. Dial. Transplant. 2006; 21: 1549-1554.
  10. Sallee M.,DanielL.,Piercecchi M., Jaubert D.,Fremeaux-Bacchi V., Berland Y., Burtey S. Myocardial infarction is a complication of factor H associated atypical HUS. Nephrol. Dial. Transplant. 2010; 25: 2028-2032.
  11. Hawkins B.M., Abu-Fadel M., Vesely S.K., George J.N. Clinical cardiac involvement in thrombotic thrombocytopenic purpura: a systematic review. Transfusion. 2008; 48: 382-392.
  12. Moschcowitz E. An acute febrile pleiochromic anemia with hyaline thrombosis of the terminal arterioles and capillaries: an undescribed disease. Arch. Intern. Med. 1925; 36: 89-93.
  13. Sane D.C., Streer N.P., Owen J. Myocardial necrosis in patients with thrombotic thrombocytopenic purpura: pathophysiology and rationale for specific therapy. Eur. J. Haematol. 2008; 82: 83-92.
  14. Huges C., Mc Ewan J.R., Longair I., Hughes S., Cohen H., Machin S., Scully M. Cardiac Involvement in acute thrombotic thrombocytopenic purpura: association with troponin T and IgG antibodies to ADAMTS 13. J. Thromb. Haemost. 2009; 7: 529-536.
  15. Machol K., Vivante A., Rubinsthein M., Dekel B., Danieli J., Paret G. Keeping the heart in mind when managing hemolytic uremic syndrome. IMAJ. 2011; 13: 446-447.
  16. Noris M., Caprioli J., Bresin E., Mossali C., Pianetti G., Gamba S., Daina E., Fenili C., Castelletti F., Sorosina A., Piras R., Donadelli R., Maranta R., van der Meer I., Conway E.M., Zipfel P.F., Goodship T.H., Remuzzi G. Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype. Clin. J. Am. Soc. Nephrol. 2010; 5: 1844-1859.
  17. Ridolfi R.L., Hutchins G.M., Bell W.R. The heart and cardiac conduction system in thrombotic thrombocytopenic purpura. A clinicopathologic study of 17 autopsied patients. Ann. Intern. Med. 1979; 91: 357-363.
  18. Ghandhi K., Aronow W., Desai H., Amin H., Sharma M., Lai H.M., Singh P. Cardiovascular manifestations in patients with thrombotic thrombocytopenic purpura: a single-center experience. Clin. Cardiol. 2010; 33(4): 213-216.
  19. Podolsky S.H., Zembowicz A., Schoen F.J., Benjamin R.J., Sonna L.A. Massive myocardial necrosis in thrombotic thrombocytopenic purpura: a case report and review of the literature. Arch. Pathol. Lab. Med. 1999; 123(10): 937-940.
  20. Rother R., Bell L., Hillmen P., Gladwin M.T. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin. A novel mechanism of human disease. JAMA. 2005; 293: 1653-1652.
  21. Studt J.D., Hovinga J.A., Antoine G., Hermann M., Rieger M., Scheiflinger F., Lämmle B. Fatal congenital thrombotic thrombocytopenic purpura with apparent ADAMTS 13 inhibitor: in vitro inhibition of ADAMTS 13 activity by hemoglobin. Blood. 2005; 105: 542-544.
  22. Ronco C., Haapio M., House A.A. Cardiorenal syndrome. JACC. 2008; 52(19): 1527-1539.
  23. Ridolfi R.L., Bell W.R. Thrombotic thrombocytopenic purpura. Report of 25 cases and review of the literature. Medicine (Baltimore). 1981; 60: 413-428.
  24. Scully M., Hunt B.J., Benjamin S., Liesner R., Rose P., Peyvandi F., Cheung B., Machin S.J. on behalf of British Committee for Standards in Haematology. Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies. Brit. J. Haematol. 2012; 10(1111): 1365-2141.
  25. Brandenburg V.M., Gaertner S., Lindemann-Docter K., Ortlepp J.R., Westerhuis R., Ketteler M., Westenfeld R., Floege J. Underestimated complications in thrombotic thrombocytopenic purpura - hemolytic uremic syndrome. Nephrol. Dial. Transplant. 2004; 19: 2142-2146.

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