Modern concept of the renal transport mechanisms of uric acid


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Abstract

The results of recent genetic studies, wide application of methods for studying genome association (GWAS), expression systems, and biological models allow for new insights into the renal transport of uric acid and its disturbances having important pathophysiological significance. Identification of urate transporters URATI and GLUT9 triggered the idea of urate transport system of the proximal tubules of the human kidneys. That has called into question the legitimacy of recently dominant the four-component model of renal urate transport and led to the emergence of the concept of multimolecular complex transporting urate - urate ransportosome. Recent Gwas-studies revealed about io genes coding for relevant urate transporters associated with levels of serum uric acid. Their mutations were found to cause the development of renal hyperuricemia. Identification of the urate transporters offers the prospect of developing new uricosuric medications that could become potential alternatives to treat patients with refractory gout.

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Ya. F Zverev

Email: zver@asmu.ru

V. M Bryukhanov

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