Renal dysfunction - predictor for prognosis in patients with ST-segment elevation acute myocardial infarction
- Authors: Vakulchik K.A1, Mezhonov E.M2, Vyalkina Y.A2, Shalaev S.V1
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Affiliations:
- FSBEI HE "Tyumen State Medical University” of RMH
- SBHCI TR "Regional Clinical Hospital №1"
- Issue: No 3 (2017)
- Pages: 4-9
- Section: Articles
- URL: https://journals.eco-vector.com/2075-3594/article/view/272619
- ID: 272619
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Abstract
Aim. to evaluate the prognostic value of kidney damage in patients with ST-segment elevation acute myocardial infarction (STEMI) in a prospective 6-month observational study. Material and Methods. a prospective 6-month observational study included 241 patients with STEMI. The kidney function was evaluated by calculating the creatinine clearance using the CKD-EPI formula. An evaluation of the effect of renal dysfunction on cad outcomes for 6 months was carried out. The endpoints of the study included: hospital mortality, cardiovascular mortality during follow-up, readmissions for acute coronary syndrome (Acs). Results. 41.1% of patients had renal dysfunction (GFR <60 mL/min). Hospital mortality was rec-orded in 9.5% of cases; the highest mortality rate was recorded in the group of patients with GFR <60 ml/min - 17.2%, while among patients with GFR> 60 ml/min - 4.2% (p=0.001). Hospital mor-tality with GFR from 45 to 59 ml/min was 6.3%, GFR from 30 to 44 ml/min - 42.9%, GFR from 15 to 29 ml/min - 60.0% (p<0.001). GFR <60 ml/min increases the risk of the combined primary end-point by 3 times (RR 95% 2.917 (1.360-6.254, p=0.006), GFR from 45 to 30 ml/min - by 8 times (RR 95% 7.714 (2,076-28,661, P=0,002), and GFR from 30 to 15 ml/min - by 10 times (RR 95% 10,286 (2,383-44,398, P=0,002). Conclusions. In patients with STEMI, a decrease in GFR is an unfavorable predictor of fatal out-come within 6 months of follow-up.
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About the authors
K. A Vakulchik
FSBEI HE "Tyumen State Medical University” of RMH
Email: vakulchik_91@mail.ru
Postgraduate Student at the Department of Cardiology and Cardiac Surgery of the ICPE with a Course of EMC
E. M Mezhonov
SBHCI TR "Regional Clinical Hospital №1"PhD in Medical Sciences, Cardiologist
Yu. A Vyalkina
SBHCI TR "Regional Clinical Hospital №1"PhD in Medical Sciences, Cardiologist
S. V Shalaev
FSBEI HE "Tyumen State Medical University” of RMHDoctor of Medical Sciences, Professor, Head of the Department of Cardiology and Cardiac Surgery with the Course of EMC of the ICPE
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