Urinary biomarker of podotsitarian dysfunction: importance for early diagnosis of kidney damage to type 2 diabetes mellitus
- Authors: Yarkova N.A1, Borovkov N.N1
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Affiliations:
- Nizhny Novgorod State Medical Academy
- Issue: No 3 (2017)
- Pages: 10-13
- Section: Articles
- URL: https://journals.eco-vector.com/2075-3594/article/view/272624
- ID: 272624
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Open Access
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Abstract
Aim. To determine the urinary nephrin excretion levels and clarify its significance as an early marker of kidney damage in type 2 diabetes mellitus (DM2). Materials and Methods. 97 patients with type 2 diabetes mellitus were examined. The mean age of the patients was 56 [51,7, 64] years; according to the medical history, the average duration of DM2 was 7.6 [1.5, 8.9] years. All patients underwent determination of with nephrin, microalbumin, creatinine levels, and glomerular filtration rate (GFR) was calculated by formulas. Results. According to the results of study, an increase in the urine nephrin levels was detected in all the examined DM2 patients. Nephrinuria in diabetic nephropathy correlates with albuminuria, creatinine and glycosylated hemoglobin levels, blood pressure, and GFR. Conclusion. Structural and functional disorders of podocytes associated with metabolic, endocrine and hemodynamic disorders in type 2 diabetes mellitus are already observed at the early stages of the formation of diabetic nephropathy (DN), preceding the development of clinically significant albuminuria.
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About the authors
N. A Yarkova
Nizhny Novgorod State Medical Academy
Email: E.mail: n.yarkova@mail.ru
PhD in Medical Sciences, Associate Professor at the Department of Hospital Therapy n.a. V.G. Vogralik
N. N Borovkov
Nizhny Novgorod State Medical AcademyDoctor of Medical Sciences, Professor, Head of the Department of Hospital Therapy n.a. V.G. Vogralik
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