KIM-1 as the biomarker of acute kidney injury in patients with the acute coronary syndrome and oncological diseases


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Abstract

Background. Patients with acute coronary syndrome (Acs) and oncological diseases (OD) have the increased risk of development of acute kidney injury (AKI) that can worsen the prognosis of a disease. kim-1 (kidney injury molecule) is a perspective biomarker for early diagnostics of aki. Objective. Evaluation of diagnostic and predictive value of urinary kim-1 levels in patients with Acs and OD. material and methods. The study included 87 patients. patients were divided in two groups: 1) main group: acs in combination with od (ACS+od; n=40); 2) comparison group: acs without od (ACS-od; n=47). on the first day of admission to the hospital, average portion of morning urine was collected in order to determine the kim-1 level (pg/ml). results. The median urinary kim-1 level in acs patients (n=87) was 725.6 (420.0-1087.5) pg/ml. patients in the acs+od group had higher kim-1 levels 921.o (425.i-1314.8) and 658.o (з45.6-921.4) pg/ml (P=o.oii). in patients with aki (n=28) compared to the patients without aki (N=59), urinary kim-1 level was higher: 999.3 (478.7-1303.3) and 668.2 (365.5-955.6) pg/ml (P =o.023). roc analysis revealed that urinary kim-1 level > 1047.23 pg/ml allowed to predict the development of contrast-induced aki (CI-AKI) in acs patients after selective coronary angiography (N=79) (AUC - 0.774; 95% CI, 0.666-0.860; р 1221.49 pg/ml. conclusion. The increased urinary kim-1 level was observed in development of aki; however, kim-1 showed the greatest importance as an early biomarker of ci-aki.

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About the authors

Zinaida D. Mikhailova

City Clinical Hospital № 38, Nizhny Novgorod

Email: zinaida.mihailowa@yandex.ru
Dr.Sci. (Med.), Associate Professor

Dmitry V. Pivovarov

City Clinical Hospital № 38, Nizhny Novgorod

Email: pivovarov121094@yandex.ru
Therapist

Svetlana M. Rumyantseva

Nizhny Novgorod Regional Hospital n.a. N.A. Semashko

Email: smrumyantseva@yandex.ru
Head of the Urgent Cardiology Intensive Care Unit

Almira R. Pivovarova

City Clinical Hospital № 38, Nizhny Novgorod

Email: medicinonline@yandex.ru
Therapist

References

  1. Кардиология: национальное руководство. Под ред. Е.В. Шляхто. М., 2019. 800 с. [Cardiology: national guidelines. Ed. E.V. Shlyakhto. M., 2019. 800p. (In Russ.)].
  2. Абузарова Г.Р. Боль в онкологии: грани проблемы. Мед. совет. 2018;19:97- 100.
  3. Овчинников А.Г., Виценя М.В., Агеев Ф.Т. Роль кардиолога в ведении больных, получающих антрациклины. Раннее выявление и профилактика антрациклиновой кардиомиопатии. Сердечная недостаточность. 2015;16(6):396-404. [Ovchinnikov A.G., Vitsenya M.V., Ageev F.T. The role of the cardiologist in the management of patients receiving anthracyclines. Early detection and prevention of anthracycline cardiomyopathy. Serdechnaya Nedostatochnost’. 2015;16(6):396-404. (In Russ.)]. doi: 10.18087/rhff.2015. 6.2159.
  4. Плохова Е.В., Дундуа Д.П. Основные принципы профилактики и лечения кардиотоксичности на фоне химиотерапии у онкологических пациентов. Клин. практика. 2019;10(1):31-41. [Plokhova E.V., Dundua D.P Basic principles of prevention and treatment of cardiotoxicity during chemotherapy in cancer patients. Klinicheskaya praktika. 2019;10(1):31-41. (In Russ.)]. doi: 10.17816/clinpract10130-40.
  5. Буланова М.Л., Зайцева В.П., Буланов Н.М. Клиническая характеристика и отдаленные исходы поражения почек у пациентов с острым коронарным синдромом. Нефрология. 2019;23(приложение 1):45-6. [Bulanova M.L., Zaitseva V.P, Bulanov N.M. Clinical characteristics and long-term outcomes of kidney disease in patients with acute coronary syndrome. Nefrol. 2019;23(prilozhenie 1):45-6. (In Russ.)]. doi: 10.36485/1561-6274-201923-5-23-54.
  6. Джумабаева Б.Т., Бирюкова Л.С. Новые аспекты патофизиологии и патоморфологии поражений почек при злокачественных опухолях. Клин. онкогематология. 2015;8(4):390-96. [Dzhumabayeva B.T., Biryukova L.S. New aspects of the pathophysiology and pathomorphology of renal lesions in malignant tumors. Klin. Onkogematol. 2015;8(4):390-96. (In Russ.)].
  7. Kitchlu A., McArthur E., Amir E., et al. Acute Kidney Injury in Patients Receiving Systemic Treatment for Cancer: A Population-Based Cohort Study. J. Natl. Cancer Inst. 2019;111(7):727-36. doi: 10.1093/jnci/djy167.
  8. Li Q., Huang Y., Shang W, et al. The Predictive Value of Urinary Kidney Injury Molecular 1 for the Diagnosis of Contrast-Induced Acute Kidney Injury after Cardiac Catheterization: A Meta-analysis. J. Interv. Cardiol. 2020;2020:4982987. doi: 10.1155/2020/4982987.
  9. Tsai T.T., Patel U.D., Chang T.I., et al. Validated contemporary risk model of acute kidney injury in patients undergoing percutaneous coronary interventions: insights from the National Cardiovascular Data Registry Cath-PCI Registry. J. Am. Heart Assoc. 2014;3(6):e001380. doi: 10.1161/JAHA. 114.001380.
  10. Межонов Е.М., Вялкина Ю.А., Вакульчик К.А. и др. Острое повреждение почек, индуцированное контрастным веществом, у больных инфарктом миокарда с подъемом сегмента ST после чрескожного коронарного вмешательства. Кардиология. 2018;58(8):5-11
  11. Torregrosa I., Montoliu C., Urios A., et al. Urinary KIM-1, NGAL and L-FABP for the diagnosis of AKI in patients with acute coronary syndrome or heart failure undergoing coronary angiography. Heart Vessels. 2015;30(6):703-11. doi: 10.1007/s00380-014-0538-z.
  12. Российское кардиологическое общество. Клинические рекомендации. Острый инфаркт миокарда с подъемом сегмента ST электрокардиограммы. 2020. [Электронный ресурс]. URL: https://scardio.ru/ content/Guidelines/2020/Clinic_rekom_OKS_sST.pdf. (дата обращения: 01.11.2020). Rossiiskoe kardiologicheskoe obshchestvo. Klinicheskie rekomendatsii. Ostryi infarkt miokarda s pod”emom segmenta ST elektrokardiogrammy. 2020. [Electronic resource]. URL: https://scardio.ru/ content/Guidelines/2020/Clinic_rekom_OKS_sST.pdf (date of the application: 05.12.2020). (In Russ.)].
  13. Российское кардиологическое общество. Клинические рекомендации. Острый коронарный синдром без подъема сегмента ST электрокардиограммы. 2019. [Электронный ресурс]. URL: https:// scardio.ru/ content/Guidelines/2020/Clinic_rekom_OKS_bST.pdf. (дата обращения: 05.12.2020). [Rossiiskoe kardiologicheskoe obshchestvo. Klinicheskie rekomendatsii. Ostryi koronarnyi sindrom bez pod”ema segmenta ST elektrokardiogrammy. 2019. [Electronic resource]. URL: https: //scardio. ru/content/Guidelines/2020/Clinic_rekom_OKS_bST.pdf. (date of the application: 01.11.2020). (In Russ.)].
  14. Смирнов А.В., Румянцев А.Ш. Острое повреждение почек. Часть I. Нефрология. 2020;24(1):67-95. [Smirnov A.V., Rumyantsev A.Sh. Acute kidney injury. Part I. Nefrologiya. 2020;24(1):67-95. (In Russ.)]. doi: 10.36485/1561-6274-2020-24-1-67-95.
  15. Научное общество нефрологов России, Ассоциация нефрологов России. Клинические рекомендации по профилактике, диагностике и лечению контраст-индуцированной нефропатии. 2016. 18 с. [Nauchnoe obshchestvo nefrologov Rossii, Assotsiatsiya nefrologov Rossii. Clinical practice guidelines for the prevention, diagnosis and treatment of contrast-induced nephropathy. 2016.18 p. (In Russ.)].
  16. Медицинская статистика: учеб. пособие. Под ред. Н.В. Трухачевой. Ростов-на-Дону: Феникс, 2017. 324 c. [Medical statistics: textbook. allowance. Ed. N.V. Trukhacheva. Rostov-na-Donu: Feniks, 2017.324 p. (In Russ.)].
  17. Schuh M.P, Nehus E., Ma Q., et al. Long-term Stability of Urinary Biomarkers of Acute Kidney Injury in Children. Am. J. Kidney Dis. 2016;67(1):56-61. doi: 10.1053/j.ajkd.2015.04.040.
  18. Ahmed S.A, Hamed M.A. Kidney injury molecule-1 as a predicting factor for inflamed kidney, diabetic and diabetic nephropathy Egyptian patients. J. Diab. Metab. Disord. 2015;14:6. doi: 10.1186/s40200-015-0131-8.
  19. Ren H., Zhou X., Dai D., et al. Assessment of urinary kidney injury molecule-1 and interleukin-18 in the early post-burn period to predict acute kidney injury for various degrees of burn injury. BMC. Nephrol. 2015;16:1-10. doi: 10.1186/s12882-015-0140-3.
  20. Канукоев К.Ю., Сергеева Н.С., Кармакова Т.А. и др. KIM-1 (kidney injury molecule 1) в моче больных почечно-клеточным раком. Онкоурология. 2020;16(3):21-8. [Kanukoev K.Yu., Sergeeva N.S., Karmakova T.A. et al. KIM-1 (kidney injury molecule 1) in urine of patients with renal cell carcinoma. Onkourol. 2020; 16(3):21-8. (In Russ.)]. doi: 10.17650/1726-9776-202016-3-21-28.
  21. Park H.S., Kim C.J., Yi J.E., et al. Contrast Volume/Raw eGFR Ratio for Predicting Contrast-Induced Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Intervention for Myocardial Infarction. Cardiorenal. Med. 2015;5:61-8. doi: 10.1159/000369940.
  22. Davenport M.S., Perazella M.A., Yee J., et al. Use of Intravenous Iodinated Contrast Media in Patients with Kidney Disease: Consensus Statements from the American College of Radiology and the National Kidney Foundation. Radiol. 2020;294(3):660-68. doi: 10.1148/radiol.2019192094.
  23. Nijssen E.C., Nelemans P.J., Rennenberg R.J., et al. Prophylaxis in High-Risk Patients With eGFR № 30 mL/min/1.73 m2: Get the Balance Right. Invest. Radiol. 2019;54(9):580-88. doi: 10.1097/RLI.0000000000000570.
  24. Миронова О.Ю., Фомин В.В. Контраст-индуцированное острое повреждение почек после чрескожных коронарных вмешательств у пациентов со стабильной ишемической болезнью сердца. Евразийский кардиологический журнал. 2020;(4):6-10. [Mironova O.Yu., Fomin V.V. Contrast-induced acute kidney injury after percutaneous coronary intervention in patients with stable coronary artery disease. Evraziiskii kardiologicheskii zhurnal. 2020;(4):6-10. (In Russ.)]. doi: 10.38109/2225-1685-2020-4-6-10.
  25. Medic B., Rovcanin B., Basta Jovanovic G., et al. Kidney Injury Molecule-1 and Cardiovascular Diseases: From Basic Science to Clinical Practice. Biomed. Res. Int. 2015;2015:854070. doi: 10.1155/2015/854070.
  26. Shao X., Tian L., Xu W., et al. Diagnostic value of urinary kidney injury molecule 1 for acute kidney injury: a meta-analysis. PloS One. 2014;9(1):e84131. doi: 10.1371/journal.pone.0084131
  27. Li W., Yu Y., He H., et al. Urinary kidney injury molecule-1 as an early indicator to predict contrast-induced acute kidney injury in patients with diabetes mellitus undergoing percutaneous coronary intervention. Biomed. Reports. 2015;3(4):509-12. doi: 10.3892/br.2015.449

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