NGAL as a marker of acute kidney injury in sepsis
- Authors: Sharipova V.K.1, Berdiev N.F.1, Lutfullaev O.K.1, Zhabborova M.I.1,2
-
Affiliations:
- Republican Scientific Center for Emergency Medical Aid
- Tashkent Medical Academy
- Issue: Vol 13, No 4 (2021)
- Pages: 39-42
- Section: Articles
- URL: https://journals.eco-vector.com/2075-3594/article/view/273769
- DOI: https://doi.org/10.18565/nephmlogy.2021A.39-42
- ID: 273769
Cite item
Open Access
Access granted
Abstract
Background. Acute kidney injury (AKl) can develop in a variety of conditions, especially in critically ill patients, and is often diagnosed late or remains undiagnosed. Clinical syptoms and routine laboratory parameters such as urine output and serum creatinine levels are late signs of kidney injury. The study and implementation into practice of new markers with high specificity at the early stages of kidney injury is an imperative of the time. the neutrophil gelatinase associated lipocalin (ngal) is one of such markers. objective. evaluation of the diagnostic and prognostic value of blood ngal level in patients with septic shock. Material and methods. 76 patients (45 men and 31 women, mean age 59.4 ± 6.2 years), diagnosed with sepsis of various etiology, were examined. aki was diagnosed according to the kdigo (Kidney disease improving global outcomes) criteria. serum ngal (sngal) levels were determined in patients at admission to the intensive care unit and 6, 24, 36 hours after. to analyze the predictive ability of ngal, the binary logistic regression method and the auc (area under curve) calculation was used. results. the sngal level in aki patients was statistically significantly higher - 172.4 (129.i-257.7) than in patients without aki - 124.3 (93.8-151.5) pg/ml (P
Keywords
Full Text
About the authors
Visolat Kh. Sharipova
Republican Scientific Center for Emergency Medical AidDr.Sci (Med.), Head of the Department of Anesthesiology and Emergency Care Tashkent, Uzbekistan
Nodirbek F. Berdiev
Republican Scientific Center for Emergency Medical Aid
Email: nodiranes52@gmail.com
Intensivist at the Surgical Intensive Care Unit Tashkent, Uzbekistan
Odilkhon K. Lutfullaev
Republican Scientific Center for Emergency Medical AidIntensivist at the Surgical Intensive Care Unit Tashkent, Uzbekistan
Mamura I. Zhabborova
Republican Scientific Center for Emergency Medical Aid; Tashkent Medical AcademyTeaching Assistant of the Department of Normal and Pathological Physiology Tashkent, Uzbekistan
References
- Jiang L., Zhu Y., Luo X. Epidemiology of acute kidney injury in intensive care units in Beijing: the multi-center BAKIT study. BMC. Nephrol. 2019;20:468.
- Liu J., Xie H., Ye Z. Rates, predictors, and mortality of sepsis-associated acute kidney injury: a systematic review and meta-analysis. BMC. Nephrol. 2020;21:318.
- Joana G., Jose Agapito F., Cristina O., Jose A.L. Acute Kidney Injury: From Diagnosis to Prevention and Treatment Strategies. J. Clin. Med. 2020;9(6):1704.
- Grynberg K., Polkinghorne K.R., Ford, S. Early serum creatinine accurately predicts acute kidney injury post cardiac surgery. BMC. Nephrol. 2017;18:93.
- Koeze J., Keus F, Dieperink W. Incidence, timing and outcome of AKI in critically ill patients varies with the definition used and the addition of urine output criteria. BMC. Nephrol. 2017;18:70.
- Kellum J.A., Romagnani P., Ashuntantang G. Acute kidney injury. Nat. Rev. Dis. Primers. 2021;7:52.
- Hoste E., Bihorac A., Al-Khafaji A. RUBY Investigators. Identification and validation of biomarkers of persistent acute kidney injury: the RUBY study. Intens. Care Med. 2020;46(5):943-53.
- KDIGO Clinical Practice Guideline for Acute Kidney Injury: Kidney Int. Suppl. 2012;2:1.
- Soto K., Papoila A.L., Coelho S., et al. Plasma NGAL for the diagnosis of AKI in patients admitted from the emergency department setting. Clin. J. Am. Soc. Nephrol. 2013;8(12):2053-63.
- Zhang C.F, Wang H.J., Tong Z.H., et al. The diagnostic and prognostic values of serum and urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin in sepsis induced acute renal injury patients. Eur. Rev. Med. Pharmacol Sci. 2020;24(10):5604-17.
- Miah O.F., Roy D.K., Chowdhury A.A., et al. Plasma Neutrophil Gelatinase Associated Lipocalin (pNGAL) Level to Identify AKI Early in Patients Undergoing Cardiac Valve Surgery. Mymensingh. Med. J. 2018;27(2):263-69.
- Кhawaja S., Jafri L., Siddiqui I. The utility of neutrophil gelatinase-associated Lipocalin (NGAL) as a marker of acute kidney injury (AKI) in critically ill patients. Biomark. Res. 2019;7:4.
- Yun X., Peijie H., Jiaxiang Z., Rui T., Wei J. Biomarkers for the diagnosis of sepsis-associated acute kidney injury: systematic review and meta-analysis. Ann. Palliative Med. 2021;10(4):12.
- Wang H.X., Mu H.B., Zheng R.Q. Neutrophil gelatinaseassociated lipocalin for the early diagnosis of sepsis in patients with acute kidney injury. J. Clin. Med. Pract. 2014;18:183-84.
- Xing H.B., Lv T., Sheng P.P. The diagnostic value of new biomarkers in sepsis patients with acute kidney injury. Chin. J. Crit. Care Med. 2013;33:507-10.
- Izabela D., Lukasz K. Plasma Neutrophil Gelatinase-Associated Lipocalin Is Useful for Predicting Mortality in Critically Ill Patients. J. Clin. Med. 2021;10(12):2576.
- Vanmassenhove J., Glorieux G., Lameire N. Influence of severity of illness on neutrophil gelatinase-associated lipocalin performance as a marker of acute kidney injury: a prospective cohort study of patients with sepsis. BMC. Nephrol. 2015;16:18.
Supplementary files
