Association of nephrolitiasis with arterial hypertension: gender specificities of comorbidity pathogenesis

Objective. evaluation of the gender specificities of the reactivity of the sympathoadrenal (sas) and renin-angiotensin (ras) systems in comorbidity of nephrolithiasis with arterial hypertension (ah). Material and methods. The study analyzed the clinical, instrumental and laboratory data of 196 patients with nephrolithiasis. the cohort was represented by 92 men and 104 women. the platelet aggregation was assessed by the turbidimetric method using a ChronoLog analyzer (usa). Adrenaline and angiotensin-2 agonists (Sigma) were used to analyze AT1 and α2-adrenergic receptors. results. ah was detected in 12.o% of the examined men and 10.4% of women. the features of the pathogenesis of nephrolithiasis comorbid with ah in men were associated with hyperreactivity of the α2-adrenergic receptor and the at1 receptor, while in women the at1 receptor had dominant activity. in men with stones in the urinary tract and ah, the values of microhematuria were higher (P <0.001) than in patients without comorbidity. In women with nephrolithiasis, this phenomenon was not manifested - the severity of microhematuria did not differ in the presence and absence of ah. when nephrolithiasis was associated with ah, there was no significant difference between men and women in the severity and frequency of hematuria; however, women had more pronounced leukocyturia (P<0.05). Conclusion. Pharmacological correction of arterial hypertension in the presence of nephrolithiasis is advisable to carry out taking into account the individual reactivity of sas and ras in men and women.

nephrolithiasis, arterial hypertension, sympathoadrenal system, renin-angiotensin system