The functional state of the kidneys and albuminuria in individuals with cardiovascular risk factors


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Objective. Assessment of the functional state of the kidneys and the albuminuria level in individuals with cardiovascular risk factors. Material and methods: The cross-sectional study included 70 outpatients with cardiovascular risk factors, mean age 66 (60; 72) years. Traditional risk factors and the presence of concomitant diseases were assessed. The calculation of the glomerular filtration rate was carried out according to the CKD-EPI formula, the albuminuria level was determined by the urine albumin/ creatinine ratio. Results: It was revealed that 20 (29%) of the examined patients had signs of CKD C3, 33 (47%) had albuminuria level A2 and higher. In the surveyed population, eGFR was associated with age (r=-0.51, P<0.05), and the level of albuminuria - with TG (r=0.31, P<0.05). In patients with abdominal obesity, the albuminuria level was statistically significantly higher, and eGFR did not depend on the presence of abdominal obesity. Conclusion: In patients with abdominal obesity, the albuminuria level, rather than eGFR, is an important prognostic marker.

Full Text

Restricted Access

About the authors

Larisa V. Mikhailova

Immanuele Kant Baltic Federal University

Email: mihalysa@mail.ru
Cand. Sci. (Med.), Associate Professor at the Department of Therapy, Medical Institute

Marina I. Shupina

Immanuele Kant Baltic Federal University

Email: mshupina@mail.ru
Cand. Sci. (Med.), Associate Professor at the Department of Therapy, Medical Institute

Vera S. Safonova

Immanuele Kant Baltic Federal University

Email: vsafonova099@gmail.com
5th year student of the Medical Institute

Viktoria V. Butova

Immanuele Kant Baltic Federal University

Email: vbutova@stud.kantiana.ru
4th year student of the Institute of Living Systems

Vera V. Sheremet

OOO "Sanatorium "Yantarny Bereg"

Head of the CDL

References

  1. National Kidney Foundation: K/DOQI clinical practice guidelines for managing dyslipidemias in chronic kidney disease. Am. J. Kidney Dis. 2003;41(Suppl. 3):S1-152.
  2. Matsushita K., van der Velde M., Astor BC., et al. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet. 2010;375(9731):2073-81.
  3. Xu Y., Li M., Qin G., et al. China Cardiometabolic Disease and Cancer Cohort (4C) Study Group; China Cardiometabolic Disease and Cancer Cohort (4C) Study Group Steering Committee. Cardiovascular Risk Based on ASCVD and KDIGO Categories in Chinese Adults: A Nationwide, Population-Based, Prospective Cohort Study. J. Am. Soc. Nephrol. 2021;32(4):927-37. doi: 10.1681/ASN.2020060856.
  4. Piscitelli P., Mangiacotti A., Marchese N., et al. Reduced glomerular filtration rate and prior cardiovascular event entail similar risk for coronary atherosclerotic burden. Eur. Rev. Med. Pharmacol. Sci. 2020;24(17):9063- 70. doi: 10.26355/eurrev_202009_22852.
  5. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int. Suppl. 2013;3:1-150.
  6. Robles N.R., Felix F.J., Fernandez-Berges D., et al. Cross-sectional survey of the prevalence of reduced estimated glomerular filtration rate, albuminuria and cardiovascular risk in a native Spanish population. J. Nephrol. 2013;26(4):675-82. doi: 10.5301/jn.5000221.
  7. Kühn A., van der Giet M., Kuhlmann M.K., et al. Kidney Function as Risk Factor and Predictor of Cardiovascular Outcomes and Mortality Among Older Adults. Am. J. Kidney Dis. 2021;77(3):386-96. Doi: 10.1053/j. ajkd.2020.09.015.
  8. Watanabe Y., Suda S., Kanamaru T., et al. High urinary albumin/creatinine ratio at admission predicts poor functional outcome in patients with acute ischaemic stroke. Nephrol. (Carlton). 2017;22(3):199-204. Doi: 10.1111/ nep.12745.PMID: 26860421.
  9. Moreira A.D., Velasquez-Melendez G., Ladeira R.M., et al. Association between Adiposity Indexes and Kidney Disease: Findingsfrom the Longitudinal Study of Adult Health (Elsa-Brazil). J. Am. Coll. Nutr. 2021;19:1-7. Doi: 10. 1080/07315724.2021.1878968.
  10. Su W., Wang J., Mu Y. Association Between Hypertriglyceridemic Waist Phenotype and Increased Urinary Albumin-Creatinine Ratio in Chinese Adults: The REACTION Study. Diab. Metab. Syndr. Obes. 2020;13:2965-74. doi: 10.2147/DMSO.S257736.
  11. Kim Y.J., Hwang S.D., Oh T.J., et al. Association Between Obesity and Chronic Kidney Disease, Defined by Both Glomerular Filtration Rate and Albuminuria, in Korean Adults. Metab. Syndr. Relat. Disord. 2017;15(8):416-22. doi: 10.1089/met.2017.0053.
  12. Ковесди К.П., Фурс С., Зоккали К. Ожирение и заболевания почек: скрытые последствия эпидемии. Клиническая нефрология. 2017;1: 3-11. Bring K.P., Force S., Zokkali K. Obesity and kidney disease: hidden consequences of the epidemic. Clinical nephrology. 2017;1:3-11 (In Russ.)].
  13. Almeida I., Caetano F., Barra S., Madeira M., Mota P., Leitäo-Marques A. Estimating glomerular filtration rate in acute coronary syndromes: Different equations, different mortality risk prediction. Eur Heart J. Acute Cardiovasc Care. 2016;5(3):223-30. doi: 10.1177/2048872615576219. Epub 2015 Mar 4. PMID: 25740222.
  14. Agarwal R., Bills J.E., Light R.P. Diagnosing obesity by body mass index in chronic kidney disease: an explanationfor the "obesityparadox?". Hypertension. 2010;56(5):893-900. doi: 10.1161/HYPERTENSI0NAHA.110.160747. Epub 2010 Sep 27. PMID: 20876448.
  15. Gasparini A., Evans M., Coresh J., Grams M.E., Norin O., Qureshi A.R., Runesson B., Barany P., Ärnlöv J., Jernberg T., Wettermark B., Elinder C.G., Carrero J.J. Prevalence and recognition of chronic kidney disease in Stockholm healthcare. Nephrol Dial Transplant. 2016;31(12):2086-2094. doi: 10.1093/ ndt/gfw354. Epub 2016 Oct 13. PMID: 27738231; PMCID: PMC5146708
  16. Xu T., Sheng Z., Yao L. Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment. Front Med. 2017;11(3):340-348. doi: 10.1007/s11684-017-0570-3. Epub 2017Aug 8. PMID: 28791668.
  17. Kovesdy C.P., Furth S.L., Zoccali C. Obesity and kidney disease: Hidden consequences of the epidemic. Afr J. Prim Health Care Fam Med. 2017;9(1):e1-e3. doi: 10.4102/phcfm.v9i1.1435. PMID: 29113441; PMCID: PMC5675922
  18. Kurata M., Tsuboi A., Takeuchi M., Fukuo K., Kazumi T. Association of Metabolic Syndrome with Chronic Kidney Disease in Elderly Japanese Women: Comparison by Estimation of Glomerular Filtration Rate from Creatinine, Cystatin C., and Both. Metab Syndr Relat Disord. 2016;14(1):40-45. doi: 10.1089/met.2015.0085. Epub 2015Nov 4. PMID: 26535975.
  19. Li Z., Woollard J.R., Wang S., Korsmo M.J., Ebrahimi B., Grande J.P., Textor S.C., Lerman A., Lerman L.O. Increased glomerular filtration rate in early metabolic syndrome is associated with renal adiposity and microvascular proliferation. Am J. Physiol Renal Physiol. 2011;301(5):F1078-87. doi: 10.1152/ajprenal.00333.2011. Epub 2011 Jul 20. PMID: 21775485; PMCID: PMC3213905.
  20. Nishi H., Higashihara T., Inagi R. Lipotoxicity in Kidney, Heart, and Skeletal Muscle Dysfunction. Nutrients. 2019;11(7):1664. doi: 10.3390/nu11071664. PMID: 31330812; PMCID: PMC6682887.
  21. Tsuruya K., Yoshida H., Nagata M., Kitazono T., Hirakata H., Iseki K., Moriyama T., Yamagata K., Yoshida H., Fujimoto S., Asahi K., Kurahashi I., Ohashi Y., Watanabe T. Association of the triglycerides to high-density lipoprotein cholesterol ratio with the risk of chronic kidney disease: analysis in a large Japanese population. Atherosclerosis. 2014;233(1):260-67. doi: 10.1016/j.atherosclerosis.2013.12.037. Epub 2014 Jan 18. PMID: 24529154.
  22. Sharma I., Liao Y., Zheng X., Kanwar Y.S. New Pandemic: Obesity and Associated Nephropathy. Front. Med. 2021;8:673556. doi: 10.3389/ fmed.2021.673556.

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies