Dynamic monitoring of the cardiovascular system and kidney function in patients with chronic kidney disease who had COVID-19

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Abstract

Objective. Evaluation of the state of the cardiovascular system and kidney function in patients with chronic kidney disease (CKD) who have had covid-19 during a one-year prospective follow-up. material and methods. a clinical follow-up and examination of 150 patients with ckd who have had covid-19 was carried out. the examination included an assessment of the cytokine profile (interleukin-1 - il-1, il-6, il-8, tumor necrosis factor a - tnf-a), determination of the of high- sensitivity c-reactive protein (CRP), ferritin, natriuretic peptide, cystatin c levels, echocardiogram, 24-hour blood pressure monitoring, estimation of the glomerular filtration rate according to the ckd-epi formula during 12-month follow-up period. results. a change in the pro-inflammatory cytokine levels, an increase in the crp level, a change in the structural and functional state of the cardiovascular system in patients at з and 12 months after covid-19 were found. there was no significant deterioration in the functional state of the kidneys in patients after з months, while after 12 months of follow-up, the number of patients with advanced ckd stages increased, especially in the group of patients with ckd and cardiovascular diseases. Conclusion. Patients with ckd who have had covid-19 need for long-term follow-up by the nephrologist and cardiologist for comprehensive monitoring of the functional state of the kidneys and the cardiovascular system and adequate cardio- and nephroprotective therapy.

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About the authors

Denis V. Zhmurov

Tyumen State Medical University

Email: zhmdenis@yandex.ru
Cand. Sci. (Med.), Associate Professor at the Department of Propaedeutics of Internal Diseases Tyumen, Russia

Vladimir A. Zhmurov

Tyumen State Medical University

Email: zhmurovva@yandex.ru
Dr.Sci. (Med.), Professor, Head of the Department of Propaedeutics of Internal Diseases Tyumen, Russia

Ivan M. Petrov

Tyumen State Medical University

Dr.Sci. (Med.), Associate Professor, Head of the Department of Medical Informatics and Biological Physics Tyumen, Russia

Tatyana I. Petelina

yumen Cardiology Research Center - Branch Campus of the Tomsk National Medical Research Center

Dr.Sci. (Med.), Leading Researcher, Department ofArterial Hypertension and Coronary Artery Insufficiency, Scientific Department of Clinical Cardiology Tyumen, Russia

Lyudmila I. Gapon

yumen Cardiology Research Center - Branch Campus of the Tomsk National Medical Research Center

Dr. Sci. (Med.), Professor, Head of the Scientific Department of Clinical Cardiology, Scientific Director of the Department of Arterial Hypertension Tyumen, Russia

Elena I. Yaroslavskaya

yumen Cardiology Research Center - Branch Campus of the Tomsk National Medical Research Center

Dr.Sci. (Med.), Head of the Laboratory of Instrumental Diagnostics Tyumen, Russia

Yulianna A. Petrova

Tyumen State Medical University

Can.Sci. (Med.), Associate Professor at the Department of Propaedeutics of Internal Diseases Tyumen, Russia

Tatyana V. Reshetnikova

Tyumen State Medical University

Can.Sci. (Med.), Associate Professor at the Department of Internal Propaedeutics Tyumen, Russia

Natalya V. Tolstoukhova

Tyumen State Medical University

Can.Sci. (Med.), Associate Professor at the Department of Propaedeutics of Internal Diseases Tyumen, Russia

Ekaterina A. Zhmurova

Tyumen State Medical University

1-year resident physician at the Department of Internal Medicine, Polyclinic Therapy and Family Medicine Tyumen, Russia

Anna A. Ermakova

Tyumen State Medical University

Email: ermackovaanka@yandex.ru
Department of Propaedeutics of Internal Diseases Tyumen, Russia

Polina A. Ermakova

Tyumen State Medical University

Email: poli263@mail.ru
Department of Propaedeutics of Internal Diseases Tyumen, Russia

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