Physiology of non-diabetic glucosuria and its role in the recurrence of urinary tract infections: methods of correction


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Background. Non-diabetic glucosuria in healthy individuals is one of the mechanisms of energy supply for the work of the nephron and can provoke the persistence of the uropathogen. Objective. Evaluation of the manifestations of non-diabetic glucosuria during positron emission tomography/computed tomography (PET/ct) with 18 f-fdg glucose and its laboratory manifestation in urinary tract infections (UTIs). material and methods. pet/ct study of molecular-cellular manifestations of non-diabetic glucosuria in 30 healthy individuals, as well as laboratory manifestations of non-diabetic glucosuria during implementation in 30 patients with recurrent UTIs was performed. results. Visual pet/ct confirmation of the formation of molecular-cellular manifestations of non-diabetic glucosuria in healthy individuals and its laboratory manifestation in patients with UTIs was obtained. The use of NefroBest-N phytocomplex leveled glucosuria and increased the efficiency of pathogen eradication. Conclusion. Non-diabetic glucosuria can be one of the reasons for the long-term persistence of the uropathogen.

Full Text

Restricted Access

About the authors

Vadim B. Berdichevsky

Tyumen State Medical University

Email: urotgmu@mail.ru
Dr. Sci. (Med.), Professor at the Department of Oncology with a Course of Urology Tyumen, Russia

Vladimir A. Zhmurov

Tyumen State Medical University

Email: zhmurovva@yandex.ru
MD, Professor, Head of the Department of Propaedeutic and Faculty Therapy Tyumen, Russia

Ekaterina V. Sapozhenkova

Tyumen State Medical University

Email: ekaterina_chibulaeva@mail.ru
Cand. Sci.(Med.), Associate Professor at the Department of Normal Physiology Tyumen, Russia

Alisia V. Romanova

Tyumen State Medical University

Email: alisochka8972@mail.ru
PhD student at the Department of Oncology with a Course of Urology Tyumen, Russia

Farkhod R. Rasulov

Tyumen State Medical University

Email: fr-doc@mail.ru
PhD student at the Department of Oncology with a Course of Urology Tyumen, Russia

Stanislav V. Khilkevich

Regional Clinical Hospital №2

Email: khilkevichstanislav@mail.ru
Head of the Department of Urology Tyumen, Russia

Artem R. Gonyaev

Tyumen State Medical University

Email: dortor_bba@mail.ru
PhD student at the Department of Oncology with a Course of Urology Tyumen, Russia

Mikhail A. Korabelnikov

Radiology Center, Multidisciplinary Clinical Medical Center “Medical City”

Email: kma_doc@mail.ru
Radiologist Tyumen, Russia

References

  1. Liman M.N.P, Jialal I. Physiology, Glycosuria. Treasure Island (FL): StatPearls Publishing; 2022 Jan.2021 Mar 24. [PMID: 32491373 Bookshelf ID: NBK557441].
  2. Ghezzi C., Loo D.D.F., Wright E.M. Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2. Diabetol. 2018;61(10):2087-97. doi: 10.1007/s00125-018-4656-5. [Epub 2018 Aug 22].
  3. Gronda E., Jessup M., Iacoviello M. Glucose Metabolism in the Kidney: Neurohormonal Activation and Heart Failure Development. J. Am. Heart Associat. 2020;9:e018889. https://doi.org/10.1161/JAHA.120.018889
  4. Ishman B., Shlomai G., Twig G., et al. Renal glucosuria is associated with lower body weight and lower rates of elevated systolic blood pressure: results of a nationwide cross-sectional study of 2.5 million adolescents. Cardiovasc. Diab. 2019;18(1):124. https://doi.org/10.1186/s12933-019-0929-7
  5. Урология. Российские клинические рекомендации. Под ред. Ю.Г. Аляева, П.В. Глыбочко, Д.Ю. Пушкаря. М., 2016. 496 с.
  6. Зайцев А.В., Ширяев А.А., Ким Ю.А. Инфекции мочевыводящих путей. Современная тактика врача-уролога. РМЖ. 2019;11:21-6.
  7. Fitzpatrick M.C., Bauch C.T., Townsend J.P., Galvani AP Modelling microbial infection to address global health challenges. Nat. Microbiol. 2019;4(10): 1612-19. doi: 10.1038/s41564-019-0565-8.
  8. Fauci A.S., Marston H.D. The Perpetual Challenge of Antimicrobial Resistance. JAMA. 2014;311(18):1853-54. doi: 10.1001/jama.2014.2465.
  9. Heesterbeek H., et al. Modeling infectious disease dynamics in the complex landscape of global health. Sci. 2015;347:aaa4339. [PMC - PubMed].
  10. Sommer F., Backhed F. The gut microbiota - masters of host development and physiology. Nat. Rev. Microbiol 2013.11:227-38. doi: 10.1038/nrmicro2974. [Cross Ref, PubMed, Google Scholar].
  11. Чехина Н.А., Чукаев С.А., Николаев С.М. Сахарный диабет: возможности фармакотерапии с использование средств растительного происхождения. Вестн. Бурятского университета. 2010;12:70-5.
  12. Berdichevskyу B.A., Berdichevskyу V.B. Non-diabetic glucosuria of the possible factors of formation of chronic kidney diasases. Global J. Urol. Nephrol. 2020;3:21. doi: 10.28933/gjun-2020-02-1305.
  13. Бердичевский Б.А., Бердичевский В.Б., Шидин В.А. и др. Канефрон Н
  14. Beerepoot M.A., Geerlings S.E., van Haarst E.P., et al. Nonantibiotic prophylaxis for recurrent urinary tract infections: a systematic review and meta-analysis of randomized controlled trials. J. Urol. 2013;190(6):1981-89. doi: 10.1016/j.juro.2013.04.142.
  15. Мартынюк А.П., Ружицкая О.А., Мартынюк Е.С. Влияние растительного препарата канефрон-Н на течение диабетической нефропатии у пациентов с сахарным диабетом. Почки. 2015;1(11):24-31.
  16. Набер К.Г., Перепанова К.Г. Обзор эффективности и безопасности препарата Канефрон® Нпри лечении и профилактике урогенитальных и гестационных заболеваний. Росс. мед. журн. 2012;18:922-25.
  17. Werner R.A., Ordonez A.A., Sanchez-Bautista J., et al. New functional PET imaging of the kidney with 18F-FDS in humans. Clin. Nucl. Med. 2019;44(5):410-11. doi: 10.1097/RLU.0000000000002494.
  18. Ruiz-Bedoya C.A., Ordonez A.A., Werner R.A., et al. 11 C-PABA as a new PET-based radioactive tracer for functional renal imaging: preclinical and early human studies. J. Nucl. Med. 2020;61:1665-71. doi: 10.2967/jnumed.119.239806.
  19. Berdichevsky V.B., Berdichevsky B.A. The combination of positron emission and computed tomography in the study of the metabolism of chronic kidney disease.Intern. J. Radiol. Radiother. 2018;5(5):293-94. Doi: 10.15406 / ijrrt.2018.05.00181.
  20. Berdichevskу V.B., Berdichevskу В.А., Romanova A.V., Rasulov F.R.Integrative Approach to Assessing the Results of PET/CT of the Human Body. Medical Research and Clinical Case Reports 2.5. USA. 2019. 298-300.
  21. Berdichevsky B.A., Berdichevsky V.B. Non-invasivepositron emission biopsy of the renal parenchyma. Usa. Scitech central. Nefrol. 2021;29:2021.

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies