Clinical cases of acute kidney injury under conditions of exposure to short-term abnormal heat waves

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Abstract

In recent years, Central Asia has seen an increase in the incidence of abnormally hot summer days, which is associated with an increased risk to public health. Exposure to elevated temperatures significantly affects the incidence of cardiovascular, respiratory, and renal diseases, which is reflected in an increase in mortality. Unlike cold, heat leads to rapid implementation of pathological changes with a shorter time lag and shorter waves. Heat waves are traditionally associated with heat stroke, heat syncope, as well as decompensation of chronic non-communicable diseases and the development of acute kidney injury (AKI). In conditions of abnormal heat, the renin-angiotensin-aldosterone and sympathetic nervous systems are activated, which is a physiological response to high temperatures. Individuals with chronic non-communicable diseases are especially susceptible to the negative effects of heat. The article presents the results of two clinical cases of AKI, the development of which occurred against the background of abnormal heat in patients with chronic diseases. Both patients showed an increase in creatinine, homocysteine, and serum interleukin-6 levels. During treatment, stabilization of the renal filtration function and a decrease in the interleukin-6 level were noted.

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About the authors

Ilkhom T. Murkamilov

Kyrgyz State Medical Academy named after I.K. Akhunbaev; Salymbekov University

Author for correspondence.
Email: murkamilov.i@mail.ru
ORCID iD: 0000-0001-8513-9279

Dr.Sci. (Med.), Associate Professor at the Department of Faculty Therapy, Director of the multidisciplinary medical center «Doc university clinic»

Kyrgyzstan, Bishkek; Bishkek

Kubanych A. Aitbaev

Research Institute of Molecular Biology and Medicine

Email: aitbaev.kuban1940@gmail.com
ORCID iD: 0000-0003-4973-039X

Dr.Sci. (Med.), Professor, Head of the Department of Pathological Physiology

Kyrgyzstan, Bishkek

Viktor V. Fomin

Sechenov University

Email: fomin_vic@mail.ru
ORCID iD: 0000-0002-2682-4417

Dr.Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Faculty Therapy No. 1, N.V. Sklifosovsky Institute of Clinical Medicine, Vice-Rector for Innovation and Clinical Activities

Russian Federation, Moscow

Furkat A. Yusupov

Osh State University

Email: furcat_y@mail.ru
ORCID iD: 0000-0003-0632-6653

Dr.Sci. (Med.), Professor, Head of the Department of Neurology, Neurosurgery and Psychiatry, Medical Faculty

Kyrgyzstan, Osh

Tursunoy F. Yusupova

Osh State University

Email: yusupova_tursunoy_f@mail.ru
ORCID iD: 0000-0002-8502-2203

Clinical Resident at the Department of Neurology, Neurosurgery and Psychiatry, Medical Faculty

Kyrgyzstan, Osh

Zulhumor F. Yusupova

Osh State University

Email: zulkhumor.yusupova.f_05@mail.ru
ORCID iD: 0000-0001-7621-1128

4th-year Student at the Faculty of Medicine

Kyrgyzstan, Osh

Gulzat K. Duysheeva

Kyrgyz State Medical Academy named after I.K. Akhunbaev

Email: guzyu_88@mail.ru

Teaching Assistant of the Department of Faculty Therapy

Kyrgyzstan, Bishkek

Shavkat Sh. Khakimov

Salymbekov University

Email: hakimovshaki13@gmail.com
ORCID iD: 0009-0004-0437-0188

Head of the Department of Resuscitation, Therapy and Diagnostics

Kyrgyzstan, Bishkek

Zhaloliddin I. Solizhonov

Kazan State Medical University

Email: jaloliddinsolijonov44@gmail.com
ORCID iD: 0009-0003-0078-0609

6th-year student at the Faculty of Medicine

Russian Federation, Kazan

Daniyar S. Ymankulov

Green Clinic Medical Center

Email: ymankulov9595@mail.ru
ORCID iD: 0009-0000-4975-1196

Researcher, Plastic Surgeon

Kyrgyzstan, Bishkek

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2. Fig. 1. Ultrasound of the liver and gallbladder

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3. Fig. 2. Ultrasound of the kidneys with Dopplerography of the vessels, bladder and prostate gland

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4. Fig. 3. Ultrasound of the liver and gallbladder

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5. Fig. 4. Ultrasound of the kidneys with Dopplerography of the vessels, bladder and prostate gland

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6. Fig. 5. Ultrasound of the bladder and prostate gland

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