New biomarkers of kidney diseases: a breakthrough in early and accurate diagnostics

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Kidney diseases pose a significant threat to public health worldwide, with early detection, timely intervention, and accurate monitoring being critical to prevent progression to end-stage kidney disease and improve patient outcomes. However, traditional markers of kidney disease, such as serum creatinine, blood urea nitrogen, and estimated glomerular filtration rate, have limitations in sensitivity and specificity in detecting early renal dysfunction. In recent years, rapid advances in molecular biology, proteomics, and metabolomics have led to the discovery of a number of new biomarkers that are gradually finding application in clinical practice. This mini-review discusses some of the emerging biomarkers of kidney disease, including cystatin C (Cys-C), neutrophil gelatinase-associated lipocalin (NGAL), and kidney injury molecule-1 (KIM-1), which have become valuable tools for the early detection of renal failure, paving the way for improved clinical management and quality of patient care. Despite the enormous potential of these markers, issues such as standardization, cost-effectiveness, and large-scale validation still need to be addressed before they can be widely used. Future research should be aimed at optimizing detection methods, establishing clinical decision thresholds, and assessing the value of these markers in personalized medicine, thereby paving new avenues for accurate diagnosis and treatment of kidney diseases.

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作者简介

Kubanych Aitbaev

Salymbekov University

编辑信件的主要联系方式.
Email: aitbaev.kuban1940@gmail.com
ORCID iD: 0000-0003-4973-039X

Dr.Sci. (Med.), Professor, Consultant of the Resuscitation, Therapy and Diagnostics Department of the Multidisciplinary Medical Center

吉尔吉斯斯坦, Bishkek

Ilkhom Murkamilov

Salymbekov University; I.K. Akhunbaev Kyrgyz state medical academy

Email: murkamilov.i@mail.ru
ORCID iD: 0000-0001-8513-9279

Dr.Sci. (Med.), Corresponding Member of the Russian Academy of Natural Sciences, Associate Professor, Department of Faculty Therapy, Director of the Multidisciplinary Medical Center «Doc University Clinic»

吉尔吉斯斯坦, Bishkek; Bishkek

Viktor Fomin

Russian Medical Academy of Continuous Professional Education

Email: fomin_vic@mail.ru
ORCID iD: 0000-0002-2682-4417

Dr.Sci. (Med.), Professor, Academician of the Russian Academy of Sciences, Rector

俄罗斯联邦, Moscow

Zhamila Murkamilova

Family Medicine Center №7

Email: murkamilovazh.t@mail.ru
ORCID iD: 0000-0002-7653-0433

therapist

吉尔吉斯斯坦, Bishkek

Zafarbek Raimzhanov

N.N. Burdenko Main Military Clinical Hospital

Email: rzrmam@mail.ru
ORCID iD: 0000-0001-5746-6731

Neurologist, 29th Neurological Department

俄罗斯联邦, Moscow

Furkat Yusupov

Osh State University

Email: furcat_y@mail.ru
ORCID iD: 0000-0003-0632-6653

Dr.Sci. (Med.), Professor, Head of the Department of Neurology, Neurosurgery and Psychiatry, Medical Faculty

吉尔吉斯斯坦, Osh

Abdulkhokim Yusupov

Osh State University

Email: furcat_y@mail.ru
ORCID iD: 0000-0002-6449-8229

Teaching Assistant, Department of Neurology, Neurosurgery and Psychiatry, Medical Faculty

吉尔吉斯斯坦, Osh

Tursunoy Yusupova

Osh State University

Email: yusupova_tursunoy_f@mail.ru
ORCID iD: 0000-0002-8502-2203

Clinical Resident at the Department of Neurology, Neurosurgery and Psychiatry, Medical Faculty

吉尔吉斯斯坦, Osh

Zulhumor Yusupova

Osh State University

Email: yusupova_tursunoy_f@mail.ru
ORCID iD: 0000-0001-7621-1128

5th-year student of the Faculty of Medicine

吉尔吉斯斯坦, Osh

Altynay Baitelieva

I.K. Akhunbaev Kyrgyz state medical academy

Email: altynaibaitelieva.k@gmail.com
ORCID iD: 0000-0001-6668-9451

Cand.Sci. (Med.), Head of the Department of Scientific, Innovative and Clinical Work

吉尔吉斯斯坦, Bishkek

参考

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