Acute occlusion of renal arteries in children with hereditary thrombophylia


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Abstract

Aim. Determination of criteria of diagnosis of renal infarction in children and estimation of risk factors of renal vessels thrombosis in children with hereditary thrombophylia.
Methods. 66 children (age 1 - 18 years) were included into the study. 44 patients carried genetic markers of thrombophylia and had episodes of thrombosis in relatives; 22 children had genetic markers of thrombophylia and undergone at least one episode of thrombosis of various localization. 20 healthy children served as controls. In all children genetic studies, determination of plasma levels of homocysteine and lipoprotein (a), coagulological parameters and Doppler ultrasound scanning of kidneys were performed.
Results. Assessment of haemostasis genes revealed various genotypic associations. In 8 children with hereditary thrombophylia ultrasound signs of renal infarction were found.
Conclusion. Risk of renal infarction is higher in children, who carry genetic markers of thrombophylia, especially in those, who demonstrate elevation of plasma lipoprotein (a) level more than 2 times above the control parameters.

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