Clinical assessment of circulating (pro-ANP) and renal interstitial (CGMP) natriuretic peptides in proteinuric forms of chronic glomerulonephritis

Aim. Detrmination of correlation of precursor of atrial natriuretic peptide (pro-ANP) and urinary excretion of circulating GMP (cGMP) and their relationship with activity of chronic glomerulonephritis (CGN). Methods. 47 patients with CGN (28 male, 19 female, age і7-62 years) were divided into several groups: 1st (n=10) - with nephrotic syndrome and renal failure, 2nd (n=14) - with nephrotic syndrome without renal failure, 3rd - with non-nephrotic proteinuria, 4th - with hematuria, 9 healthy volunteers served as controls. In all patients plasma level of pro-ANP and urinary excretion of cGMP were determined. Results. Urinary excretion of cGMP in healthy volunteers was higher, than in patients with CGN, in whom it’s level depended on the activity of renal damage. Patients with nephrotic syndrome had lowest levels of urinary cGMP, especially those with renal failure. Plasma pro-ANP level directly correlated with CGN activity. Conclusion. Determination of plasma pro-ANP level and cGMP excretion can be used for determination of chronic glomerulonephritis activity and prognosis.

natriuretic peptide, atrial natriuretic peptide, cGMP, nephrotic syndrome, chronic glomerulonephritis