Urinary level of podocyte damage and self-defence markers in patients with chronic glomerulonephritis


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Аннотация

Aim. Assessment of severity of podocyte damage in patients with chronic glomerulonephitis (CGN) according to proteinuria level and urinary excretion of interleuki-6 (IL-6) and heat shock protein-27 (HSP-27). Methods. 73 patients with CGN were included into the study; 30 of the — with nephrotic syndrome. Podocyturia was assessed by floucytometry with podocalixin-marked antibodies, urinary levels of IL-6 and HSP-27 were detetmined by Elisa. Results. Pateints with active CGN demonstrate high levels of podocyturia, correlating with proteinuria, seveirity of nephrotic syndrome and urinary excretion of IL-6. Podocituria detects unfavorable renal prognosis. Conclusion. Podocituria can be used as a marker of disease severity and prognosis in patients with chronic glomerulonephritis.

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Әдебиет тізімі

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