Urinary level of podocyte damage and self-defence markers in patients with chronic glomerulonephritis
- Authors: Tchebotareva N.V1, Neprintseva N.V1, Es’kova O.A1, Bobkova I.N1, Kozlovskaya L.V1
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- Issue: No 4 (2013)
- Pages: 33-37
- Section: Articles
- URL: https://journals.eco-vector.com/2075-3594/article/view/261817
- ID: 261817
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Abstract
Aim. Assessment of severity of podocyte damage in patients with chronic glomerulonephitis (CGN) according to proteinuria level and urinary excretion of interleuki-6 (IL-6) and heat shock protein-27 (HSP-27). Methods. 73 patients with CGN were included into the study; 30 of the — with nephrotic syndrome. Podocyturia was assessed by floucytometry with podocalixin-marked antibodies, urinary levels of IL-6 and HSP-27 were detetmined by Elisa. Results. Pateints with active CGN demonstrate high levels of podocyturia, correlating with proteinuria, seveirity of nephrotic syndrome and urinary excretion of IL-6. Podocituria detects unfavorable renal prognosis. Conclusion. Podocituria can be used as a marker of disease severity and prognosis in patients with chronic glomerulonephritis.
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About the authors
N. V Tchebotareva
N. V Neprintseva
O. A Es’kova
I. N Bobkova
Email: irb0.mma@mail.ru
L. V Kozlovskaya
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