Endothelial dysfunction in patients with chronic kidney disease: prognostic potential of endothelin-1


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Аннотация

Objective. to assess the relationship between the serum level of endothelin-1, renal function, and the presence and severity of endothelial dysfunction. material and methods. 80 ckd patients aged 26 to 79 (58.9±i.4) years were selected for this study: 43 women (average age 60.i±i.9 years) and 37 men (average age 57.4±2.з years). the cohort of patients was divided into 2 groups: group 1 consisted of 40 patients (28 women and 12 men) with ckd за-5 (average age 59.9±2.i years), group 2 - 40 patients (18 women and 22 men) with ckd 5D (average age 58.i±2.i years). in all patients, clinical and anamnestic data were assessed, laboratory studies were carried out, the serum level of endothelin-1 was determined, bioimpedance analysis was performed, a test with endothelium-dependent vasodilation was performed using ultrasound examination of the brachial artery. Statistical analysis was performed using statistica io.o software. results. the level of endothelin-1 was higher in the group of patients receiving treatment with programmed hemodialysis: 54.i±o.7 pg/ml versus 45.7±i.4 pg/ml, respectively. the prevalence of endothelial dysfunction in the general cohort of patients according to the test data was 48.8% of cases (in the 1st group - 27.5%, and in the 2nd group - 70%; p=0.001). a strong negative correlation was found between endothelin-1 and gfr. moderate correlation of endothelin-1 was found with urea, abnormalities in total fluid volume, extracellular fluid volume, duration of ckd, sodium and total serum protein levels. endothelin-1 values were higher than the median in 17.5% in group 1 and 55% in group 2. in the 2nd group, there was more often a concomitant increase in the level of endothelin-1 and a positive test with endothelial vasodilation than in the 1st group, 30% versus 2.5%. Conclusion. our study allowed us to assess the prevalence and severity of endothelial dysfunction in patients with ckd at different stages. The endothelium-dependent vasodilation test can be used as an additional assessment method. Endothelin-1 has shown a high predictive potential for endothelial dysfunction.

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Авторлар туралы

Mitkhat Gasanov

FSBEI he Rostov State Medical University

Email: mitkhat@mail.ru
Cand. Sci. (Med.), Associate Professor of the Department of Internal Diseases №1

Mane Panchenko

FSBHI Rostov Clinical Hospital «SRMC FMBA»

Email: manekydravaia@mail.ru
endocrinologist, outpatient department

Mikhail Batyushin

FSBEI he Rostov State Medical University

Email: batjushin-m@rambler.ru
Dr. Sci. (Med.), Professor, Professor of the Department of Internal Diseases №2

Natalia Bronovitskaya

FSBEI he Rostov State Medical University

Email: sadovnichaya@list.ru
Cand. Sci. (Med.)

Alexandra Razina

FSBEI he Rostov State Medical University

Email: pasechnik-alexandra@mail.ru
Cand. Sci. (Med.)

Әдебиет тізімі

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