Mukhin Role of podocin gene mutations in assessment of resistance of proteinuric nephritis to standard immunosupressive therapy


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Resumo

Aim. Estimation of risk factors of steroid-resistance, including podocin gene polymorphisms, in patients with chronic glomerulonephritis (CGN) and nephrotic syndrome (NS). Methods. 54 patients (31 male, 23 female, mean age 34 years) with CGN and NS were included into the study. All patients undergone kidney biopsy. Podocin gene polymorphisms were identified. Results. In 66 % of patients rs1410592 mutation of podocin gene was detected, in 50 % - RS1410591 mutation, mutations S1079291, IVS5+69T, RS1079292, IVS7+7AG, GLU87term, RS12401708, RS38185887, RS61747728, RS3738423, RS2274624 were found less often. Patients with CGN and NS, resistant to steroid therapy, who had combination of rs1410592 и rs1410591 podocin gene mutation, had lowest serum albumin levels and maximal proteinuria. Conclusion. Podocin gene mutations can be considered as one of the causes of steroid-resistance in patients with chronic glomerulonephritis and nephrotic syndrome.

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Bibliografia

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