The significance of TNF-α in the pathogenesis of protein-energy malnutrition in patients on program hemodialysis
- Autores: Yakovenko A.A.1, Lavrishcheva Y.V.2, Rumyantsev A.S.3, Belskikh A.N.4
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Afiliações:
- Pavlov University
- Almazov National Medical Research Center
- Saint Petersburg State University
- S.M. Kirov Military Medical Academy
- Edição: Volume 15, Nº 3 (2023)
- Páginas: 24-29
- Seção: Original Articles
- URL: https://journals.eco-vector.com/2075-3594/article/view/624723
- DOI: https://doi.org/10.18565/nephrology.2023.3.24-29
- ID: 624723
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Resumo
Objective. Assessment of the relationship between the blood serum tumor necrosis factor α (TNF-α) level and indicators of protein-energy malnutrition in patients on program hemodialysis (PH).
Material and methods. 645 patients on PH, including 300 men and 345 women aged 56.8±12.8 years were examined. All patients received treatment with program hemodialysis for 8.4±5.3 years. The assessment of nutritional status for the purpose of diagnosing protein-energy malnutrition (PEM) was performed using the method proposed by ISRNM (International Society of Renal Nutrition and Metabolism). Determination of the blood serum TNF-α level was carried out using a method based on a three-stage "sandwich" version of enzyme-linked immunosorbent assay with mono- and polyclonal anti-TNF-α antibodies using commercial kit "alpha-TNF ELISA-BEST", Vector-Best Company, Russia, in accordance with the manufacturer's instructions. Reference values for TNF-α were 0–8.1 pg/mL.
Results. The prevalence of PEM diagnosed by the ISRNM method was 24.9% (160 patients). Mean values of TNF-α in patients without signs of PEM were 7.11±3.02, and in patients with PEM they were more than twofold higher - 19.5±5.9 (P<0.001). Patients with elevated TNF-α levels showed statistically significantly lower values of the main indicators of PEM (body mass index, skeletal muscle mass index, percentage of body fat, as well as total protein, albumin, prealbumin, total cholesterol, transferrin, and the number of blood lymphocytes) than in patients with normal TNF-α levels. A significant relationship between the adequacy of the HD dose (spKt/V) and the TNF-α level was not revealed, which was confirmed, in particular, by the Spearman correlation coefficient (Rs=0.012; P=0.754). At the same time, no relationship was found between the TNF-α level and the duration of HD (Rs=0.038; P=0.328).
Conclusion. The prevalence of PEM diagnosed by the ISRNM method in patients on PH was 24.9%. An increase in the blood serum TNF-α level may be an important pathogenetic link in the development of PEU in patients receiving treatment with PH.
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Sobre autores
Aleksandr Yakovenko
Pavlov University
Autor responsável pela correspondência
Email: leptin-rulit@mail.ru
ORCID ID: 0000-0003-1045-9336
Cand.Sci (Med.), Associate Professor at the Department of Nephrology and Dialysis
Rússia, 6-8 Lev Tolstoy st., Saint Petersburg, 197022Yuliya Lavrishcheva
Almazov National Medical Research Center
Email: lavrischeva@gmail.com
ORCID ID: 0000-0002-3073-2785
Cand.Sci (Med.), Associate Professor at the Department of Faculty Therapy with the Clinic
Rússia, 2 Akkuratov st., Saint Petersburg, 197341Aleksandr Rumyantsev
Saint Petersburg State University
Email: rash.56@mail.ru
ORCID ID: 0000-0002-9455-1043
Dr.Sci. (Med.), Professor at the Department of Faculty Therapy, Faculty of Medicine
Rússia, 7/9 Universitetskaya embankment, Saint Petersburg, 199034Andrey Belskikh
S.M. Kirov Military Medical Academy
Email: vmeda_12@mil.ru
ORCID ID: 0000-0002-0421-3797
Dr.Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Nephrology and Efferent Therapy, S.M. Kirov Military Medical Academy
Rússia, 6 Academician Lebedev st., Saint Petersburg, 194044Bibliografia
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