ROL' AL'DOSTERONA V PORAZhENII POChEK PRI METABOLIChESKOM SINDROME, ASSOTsIIROVANNOM S OZhIRENIEM
- 作者: Kutyrina IM1, Kryachkova AA1, Savel'eva SA1, Shestakova MV1
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- 期: 编号 4 (2010)
- 页面: 34-44
- 栏目: Articles
- URL: https://journals.eco-vector.com/2075-3594/article/view/245887
- ID: 245887
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Aim of the study. To determine role of aldosterone in chronic kidney disease development in metabolic syndrome, associated with obesity.
Materials and methods. 79 patients with metabolic syndrome (64,6% male, 35,4% female, age 36 - 58 years) were included into the study. All patients were divided into 3 groups: 1st with body mass index (BMI) 25,0-29,9 kg/m², 2nd - with BMI 30,0-39,9 kg/m², 3rd - третья - с with BMI >40,0 kg/m². In al patients microalbuminuria, plasma renin activity and aldosterone concentration, insulin and HOMA-insulinoresistance (HОМА-IR) were determined.
Результаты. As BMI increased, plasma aldosterone concentration rose independently of plasma renin activity. Plasma aldosterone concentration was directly associated with lipid and glucose metabolism parameters and iverslu associated with glomerular filtration rate. Plasma aldosterone concentration was an independent determinant of microalbuminuria.
Conclusion. Rise of plasma aldosterone concentration is one of the independent risk factor of development of nephropathy, associated with metabolic syndrome and obesity.
Materials and methods. 79 patients with metabolic syndrome (64,6% male, 35,4% female, age 36 - 58 years) were included into the study. All patients were divided into 3 groups: 1st with body mass index (BMI) 25,0-29,9 kg/m², 2nd - with BMI 30,0-39,9 kg/m², 3rd - третья - с with BMI >40,0 kg/m². In al patients microalbuminuria, plasma renin activity and aldosterone concentration, insulin and HOMA-insulinoresistance (HОМА-IR) were determined.
Результаты. As BMI increased, plasma aldosterone concentration rose independently of plasma renin activity. Plasma aldosterone concentration was directly associated with lipid and glucose metabolism parameters and iverslu associated with glomerular filtration rate. Plasma aldosterone concentration was an independent determinant of microalbuminuria.
Conclusion. Rise of plasma aldosterone concentration is one of the independent risk factor of development of nephropathy, associated with metabolic syndrome and obesity.
参考
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