NEFRINURIYa KAK POKAZATEL' STRUKTURNO-FUNKTsIONAL'NYKh NARUShENIY GLOMERULYaRNOGO FIL'TRA U BOL'NYKh PROTEINURIChESKIMI FORMAMI NEFRITA


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Aim of the study. Determination of urinary excretion of nephrin as a marker of kidney damage and glomerular barrier deterioration in patients with chronic glomerulonephritis.
Materials and methods. 74 patients with chronic glomerulonephritis were included into the study - 18 with non-active nephritis (1st group), 18 - with prominent changes in urinalysis (2nd group), 38 - with nephrotic syndrome (3rd group). 10 healthy subjects were included into the control group. Urinary excretion of nephrin was determined by ELISA method. In 23 patients with nephrotic syndrome urinary excretion of nephrin was assessed according to the immunosupressive therapy efficacy.
Results. Urinary excretion of nephrin was higher in active forms of glomerulonephritis, in patients with nephrotic syndrome (3rd group) - significantly higher, than in patients with prominent changes in urinalysis (2nd group). Value of urinary excretion of nephrin was connected with presence of arterial hypertension and duration of nephrotic syndrome: <17 ng/ml in less than 6 months, >17 ng/ml in >17 ng/ml. Patients with urinary excretion of nephrin <17 ng/ml had 23-fold higher probability of nephrotic syndrome remission.
Conclusion. Urinary excretion of nephrin can be used as a marker of glomerular barrier damage, glomerulonephritis activity and immunosupressive therapy efficacy.

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