Predicting cardiovascular complications in patients in late post-acute coronary syndrome period considering the body water imbalance and renal dysfunction

Objective. To evaluate the impact of the body water imbalance on the risk of cardiovascular complications in Acs patients after myocardial revascularization, taking into account renal risk factors. Materials and methods. The study involved 120 patients with Acs who underwent myocardial revascularization. The assessment of traditional and renal risk factors (albuminuria 30-300 mg/L, GFR), as well as body water parameters was carried out. To estimate the effect of the studied risk factors, the endpoints were established upon completing the raw data processing. The endpoints included recurrent acute coronary syndrome or death registered 6 months after myocardial revascularization. Results. The study findings showed that smoking history and total cholesterol level impacted the likelihood of developing cardiovascular events (CVE). Increased intracellular fluid volume in all patients and in patients with albuminuria was found to increase the likelihood of CVE. Other indicators of the body water distribution disturbances did not produce a significant effect on the risk under study. The decrease in left ventricular ejection fraction and an increase in intracellular fluid were found to predict CVE 6 months after myocardial revascularization in Acs patients. Conclusion. In patients with ACS and myocardial revascularization, traditional risk factors were found to influence the probability of CVE. The study showed the prognostic impact of the body water distribution disturbances, determined at different stages of the study, on the risk of CVE.

acute coronary syndrome, myocardial revascularization, the imbalance of body water, hyperhydration, renal risk factors, cardiovascular risk