Features of renal blood flow and dynamics of uric acid concentration in women with pregnancy complicated by preeclampsia

Purpose. Evaluation of the role of renal blood flow in early diagnosis of pregnancy, complicated by pre-eclampsia (PE). Material and methods. The state of renal blood flow was evaluated in detail in 200 pregnant women at the gestational age of 30-34 weeks, 50 of them with the physiological course of pregnancy (Group і), 75 with mild PE (Group 2) and 75 with severe PE (Group 3). The examination of renal blood flow was performed using a Sono-scape SSI 5000 ultrasound scanner (model China) with 3.5 MHz convex probe. Dopplerometric parameters were assessed at the segmental, interlobar, and distal artery levels. The results of the study showed that with increasing severity of the PE course, the resistance of the intravenous segmental and interlobar arteries continued to increase. The resistance index (Ri) of segmental, interlobar and intrarenal arteries in women with severe PE was increased by 3.3% relative to those in the Group 2, respectively (in both groups P>0.05). The RI of the distal parts of the renal artery, remaining unchanged, was 5.8% lower than that of the intravenous segmental arteries and 3.2% lower than the resistance of the inter-renal interstitial arteries. Conclusions. Based on the results of the study, we developed an algorithm that allows to predict the development of pe, to choose the step-by-step tactics of management of pregnant women with this pathology.

dopplerometry, preeclampsia, renal blood flow, uric acid