A patient with systemic lupus erythematosus and lupus nephritis: the potentials for biological therapy


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Objective. evaluation of the clinical and laboratory dynamics of patients with systemic lupus erythematosus (SLE) and lupus nephritis (LN) during therapy with belimumab. material and methods. the study included 18 patients with sle and lupus kidney disease who received belimumab in addition to standard therapy. Evaluation of immunological parameters (anti-native double-stranded DNA antibody titers, сз, C4 complement component levels), biochemical parameters (cholesterol, creatinine, total blood protein levels), changes in clinical urinalysis (proteinuria, cylindruria, leukocyturia, erythrocyturia) was performed; dynamics of glomerular filtration rate (GFR), daily proteinuria and the selena-sledai index, obtained in different periods from the start of treatment with belimumab (о, 2, 6 and 12 months) were analyzed. results. The positive dynamics of clinical and laboratory symptoms (a decrease in the main disease symptoms, a positive dynamics of laboratory parameters and an improvement in the general condition) of patients were revealed. Conclusion. The use of belimumab at a dose of 10 mg/kg in addition to standard therapy for patients with sle and LN reduces the clinical and immunological activity of sle, decreases the level of daily proteinuria, decreases the creatinine level, and allows deescalating the dose of glucocorticosteroids taken.

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作者简介

Nemanja Damyanov

University of Belgrade

Email: nemanjadamjanov@yahoo.com
Dr.Sci. (Med.), Professor, Head of the Department of Rheumatology, Faculty of Medicine

Irina Vinogradova

Ulyanovsk Regional Clinical Hospital

Email: kazvin@yandex.ru
Cand. Sci. (Med.), Head of the Department of Rheumatology

Artem Bezgin

Kursk Regional Clinical Hospital

Email: bezgin_artem@inbox.ru
Dr. Sci. (Med.), Nephrologist, Department of Nephrology

Larisa Knyazeva

OOO Medical Center № 1, Kursk

Email: larisa.x.kniazeva@gsk.com
Dr. Sci. (Med.), Professor, Head of the Department of Rheumatology

参考

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