ZNAChENIE BALANSA MAKRO - I MIKRO ELEMENTOV V KORREGIRUYuShchEYTERAPII DISBAKTERIOZA

The investigation of intestinal microflora in 82 people from various ecologo-biological zones of permanent residence was
carried on and experimental modeling on 30 laboratory nonlinear rats was carried out. Normal indices of intestinal microflora
were revealed within the bounds of ecologo-biological optimum both in native practically healthy residents and in animals
having water and dietary intake of the given zone. On the contrary, in the majority of examined (80%) native practically healthy
residents of ecologo-biological disasters zone dysbacteriosis of III and IV degrees with marked colonizing resistance of conditioned
pathogenic and hemolytic staphylococcal microflora due to the numbers increase of colon bacilli with decreased
enzymatic activity was revealed. Taking into account conditions of ecologo-biological disasters, the specific character of influence
of anomalously unregulated levels and correlations of macro- and trace elements on colonizing resistance of intestinal
microflora of the examined was revealed. Thus, normal, physiological indices of intestinal colonizing resistance of practically
healthy residents and experimental animals are being formed by taking drinking water and foodstuffs from the zone of ecologo-
biological optimum. The results of the carried on investigations allow suggesting the direct influence of macro- and trace
elements content of water and dietary intake on regulation of species content of intestinal automicroflora.

dysbacteriosis, microelements, colonization resistance, prophylaxis, laboratory animals