Email this article Reparativnaya regeneratsiya tkaney kozhi krys pod deystviem rastitel'nykh preparatov
- Authors: Aksenova VI1, Sharipova MM1, Izvol'skaya MS1, Voronova SN1, Mel'nikova V.I.1
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Affiliations:
- Issue: Vol 10, No 3 (2011)
- Pages: 21-24
- Section: Articles
- Published: 15.09.2011
- URL: https://journals.eco-vector.com/2078-1962/article/view/608706
- ID: 608706
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Abstract
The influence of plant preparations metosept and vitanorm on posttraumatic regeneration rate of rat skin has been
investigated. We performed the dynamics of the differentiation potential of rat skin on the 2nd, 8th and 14th days after a
full thickness skin wound was made to the dorsum. The experimental animals were treated with a mixture of preparations
every day for 1 week before and for 18 days after injury. The evaluation of the injured area exhibited that regeneration of skin
most effectively occurs at local application of preparations. Oral treatment with preparations was effective in a dose of 40-60
mg/rat. The reduction of wound area and puffiness was observed at the 2nd day after the surgery and was 10% at the 8th
postoperational day, whereas in the control rats it was 40% of initial Fourteen days after the loss of the scab was observed, and
the recovery of hair growth was monitored at the 18th day. In the control group full healing of wounds was observed by 20-22
days. The highest number of dendritic cells and macrophages was revealed by immunohistochemistry in the experimental
animals at the 8th and 14th days after injury. Thus, complex application of preparations metosept and vitanorm stimulates
innate immunity, accelerates the recovery of the derma and facilitates wound healing.
investigated. We performed the dynamics of the differentiation potential of rat skin on the 2nd, 8th and 14th days after a
full thickness skin wound was made to the dorsum. The experimental animals were treated with a mixture of preparations
every day for 1 week before and for 18 days after injury. The evaluation of the injured area exhibited that regeneration of skin
most effectively occurs at local application of preparations. Oral treatment with preparations was effective in a dose of 40-60
mg/rat. The reduction of wound area and puffiness was observed at the 2nd day after the surgery and was 10% at the 8th
postoperational day, whereas in the control rats it was 40% of initial Fourteen days after the loss of the scab was observed, and
the recovery of hair growth was monitored at the 18th day. In the control group full healing of wounds was observed by 20-22
days. The highest number of dendritic cells and macrophages was revealed by immunohistochemistry in the experimental
animals at the 8th and 14th days after injury. Thus, complex application of preparations metosept and vitanorm stimulates
innate immunity, accelerates the recovery of the derma and facilitates wound healing.
About the authors
V I Aksenova
M M Sharipova
M S Izvol'skaya
S N Voronova
Viktoriya Il'inichna Mel'nikova
Email: v_melnikova@mail.ru
References
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