HIV AS AN INDEPENDENT RISK FACTOR FOR CARDIOVASCULAR DISEASES


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Abstract

There are currently over 34 million HIV-infected people worldwide. The extensive use of antiretroviral therapy has resulted in longer survival in these patients and a change in the structure of their mortality, with the role of cardiovascular diseases (CVD) being increased. In addition, the incidence of CVD among the HIV-infected is greater than that in the general population and the presence of HIV infection is an independent risk factor for CVD. Why CVD is so common among HIV-infected subjects has not been clarified so far. The paper discusses the role of conventional risk factors that are also more widely spread in this group of patients than in the general population; that of immune and endothelial dysfunction, proinflammatory status, the direct impact of HIV infection on the cardiovascular system and the role of antiretroviral therapy. Despite a large number of studies, they have failed to establish what role of HIV in the development of CVD. By taking into account the wide spread of HIV infection and the risk factors HIV-infected patients have, this problem deserves special attention and requires further investigations.

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About the authors

I. I CHUKAYEVA

N.I. Pirogov Russian National Research Medical University

Email: chukaeva@mail.ru

I. V KOMAROVA

N.I. Pirogov Russian National Research Medical University

A. V KRAVCHENKO

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare

T. E KUSHAKOVA

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare

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