ASSOCIATION OF THE COLONIC MICROFLORA WITH THE OCCURRENCE OF COLORECTAL CANCER


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Abstract

The human intestinal microflora comprises approximately 100 trillion microorganisms belonging to 36 000 species. It plays an important role in the maintenance of local and systemic homeostasis of a host macroorganism, by performing a number of vitally important functions. Impaired function of the intestinal microflora may increase the risk of developing a considerable number of diseases. The review considers the role of the intestinal microflora in the development of colorectal cancer. The analysis of the data available in the literature allows one to denote the basic groups of the mechanisms (metabolic, immune and intrinsic microbial) responsible for carcinogenesis associated with the activity of the representatives of the intestinal microflora, to identify potentially carcinogenic bacteria, and to propose theoretically and practically promising areas of the examined branch of science. The investigation of the impact of prebiotics, probiotics, and synbiotics on the risk of cancer and that of interactions between major cancer risk factors, intestinal microflora, and the probability of colorectal cancer are particularly urgent. Judging from the recent increasing trend in the number of cancer cases associated with biological carcinogens and due to continuous progress in molecular biology techniques, many associations of the representatives of the human body microflora with the risk of different types of malignancies will be discovered in the future.

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About the authors

A. G KUTIKHIN

Kemerovo State Medical Academy, Ministry of Health and Social Development of Russia

Email: antonkutikhin@gmail.com

E. B BRUSINA

Kemerovo State Medical Academy, Ministry of Health and Social Development of Russia

Yu. A POPOVA

Kemerovo State Medical Academy, Ministry of Health and Social Development of Russia

A. E YUZHALIN

Kemerovo State University

A. S ZHIVOTOVSKY

Kemerovo State Medical Academy, Ministry of Health and Social Development of Russia

N. I BRIKO

I.M. Sechenov First Moscow State Medical University, Ministry of Health and Social Development of Russia

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