ROLE OF RISK FACTORS IN THE DEVELOPMENT OF CARDIOVASCULAR DISEASE IN HIV-INFECTED PATIENTS WITH THE NATURAL HISTORY OF HIV INFECTION


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

As of now, both traditional and novel risk factors are used to assess the risk of cardiovascular disease (CVD). HIV infection is considered as an independent cardiovascular risk. Despite the fact that a large number of investigations have been conducted, there is yet no consensus of opinion on for what reason CVD is more common in HIV-infected patients than in the general population. Our investigation revealed the magnitude of traditional and novel risk factors in HIV-infected patients with the natural history of HIV infection and preserved immune function. These patients were not found to have proatherogenic shifts in the lipid and carbohydrate prof iles; at the same time they had a significantly higher level of tumor necrosis factor-a. After differentiation by smoking status, a higher level of insulin was detected in smokers infected with HIV than in non-smokers.

Full Text

Restricted Access

About the authors

Irina I. CHUKAEVA

N.I. Pirogov Russian National Research Medical University

Email: chukaeva@mail.ru

A. V KRAVCHENKO

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare

Email: alexey-kravtchenko@yandex.ru

I. V KOMAROVA

N.I. Pirogov Russian National Research Medical University

Email: irka.komarova@gmail.com

T. E KUSHAKOVA

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare

Email: tatyanaq@mail.ru

A. I KHACHIROVA

N.I. Pirogov Russian National Research Medical University

Email: asiyat-h@mail.ru

O. V SAINO

N.I. Pirogov Russian National Research Medical University

Email: Osayno@yandex.ru

References

  1. Kulasegaram R., Peters B.S., Wierzbicki A.S. Dyslipidaemia and cardiovascular risk in HIV infection. Curr. Med. Res. Opin. 2005; 21(11): 1717-1726.
  2. Triant V.A. HIV and Cardiovascular Disease. HIV/AIDS Annual Update 2010.
  3. Petoumenos K., Worm S., Reiss P. et al. Rates of cardiovascular disease following smoking cessation in patients with HIV infection: results from the D:A:D study. Seventeenth Conference on Retroviruses and Opportunistic Infections. San Francisco, 2010, abstract 124.
  4. Feingold K., Krauss R., Pang M., et al. The hypertriglyceridemia of acquired immunodeficiency syndrome is associated with an increased prevalence of low density lipoprotein subclass pattern B. J. Clin. Endocrinol. Metab. 1993; 76: 1423-1427.
  5. Attvall S., Fowelin J., Lager I. et al. Smoking induces insulin resistance--a potential link with the insulin resistance syndrome. J. Intern. Med. 1993; 233(4): 327-332.
  6. Bucher H., Richter W., Glass. T.R. et al. Small dense lipoproteins, apolipoprotein B, and risk of coronary events in HIV-infected patients on antiretroviral therapy: the Swiss HIV Cohort Study. J. Acquir. Immune Defic. Syndr. 2012; 60(2): 135-142.
  7. Cozzi-Lepri A., French M.A., Baxter J. et al. Resumption of HIV replication is associated with monocyte/macrophage derived cytokine and chemokine changes: results from a large international clinical trial. AIDS 2011; 25(9): 1207-1217.
  8. El-Sadr W.M., Mullin C.M., Carr A. et al. Effects of HIV disease on lipid, glucose and insulin levels: results from a large antiretroviral-naive cohort. HIV Med. 2005; 6(2): 114-121.
  9. The Strategies for Management of Antiretroviral Therapy (SMART) Study Group. CD4+ count - guided interruption of antiretroviral treatment. N. Engl. J. Med. 2006; 355: 2283-2296.
  10. Lane B.R., Markovitz D.M., Woodford N.L. et al. TNF-alpha inhibits HIV-1 replication in peripheral blood monocytes and alveolar macrophages by inducing the production of RANTES and decreasing C-C chemokine receptor 5 (CCR5) expression. J. Immunol. 1999; 163(7): 3653-3661.
  11. Imaoka H., Hoshino T., Takei S., Kinoshita T., Okamoto M., Kawayama T. et al. Interleukin-18 production and pulmonary function in COPD. Eur. Respir. J. 2008; 31: 287-297.
  12. Wewers M.D., Diaz P.T., Wewers M.E. et al. Cigarette Smoking in HIV Infection Induces a Suppressive Inflammatory Environment in the Lung. Am. J. Respir. Crit. Care Med. 1998; 15: 1543-1549
  13. Либов И. А., Черкесова С. В., Ройтман А. П. Современные аспекты дислипопротеинемий и практические подходы к их лечению. Московский медицинский журнал 1998; 3: 34-37.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies