Examination tactics for HBsAg-positive persons
- Authors: Kozhevnikova G.M1, Voznesensky S.L1, Efremova O.S2, Chulanov V.P2, Smetanina S.V3
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Affiliations:
- Peoples' Friendship University of Russia
- Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare
- Infectious Diseases Clinical Hospital Two, Moscow Healthcare Department
- Issue: No 1 (2015)
- Pages: 19-23
- Section: Articles
- URL: https://journals.eco-vector.com/2226-6976/article/view/278164
- ID: 278164
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Abstract
Objective. To estimate the prevalence of active forms of chronic hepatitis B (CHB) to identify those who need specific antiviral therapy and follow-up. Subjects and methods. 252,614 people in whom serum HBsAg levels were determined by an enzyme immunoassay were examined. ALT activity and serological and molecular biological markers were estimated in HBsAg-positive persons. 174 patients with CHB were examined to determine CHB activity and to decide whether they need antiviral therapy and further monitoring. Results. Based on the existing guidelines and the results of this investigation, the authors have proposed the sequence of examining HBsAg-positive persons, by taking into account the grading of blood hepatitis B virus (HBV) DNA levels, ALT activity, the degree of fibrosis, and gender characteristics. HBsAg was found in 4.1% of the examinees. Serum HBV DNA was detectable in 63.3% of the HBsAg persons. Antiviral therapy was required by 34.6% of the examined CHB patients with a high ALT activity. Conclusion. By considering the accessibility and economic constituent of diagnostic tests, the proposed examination algorithm allows the optimization of follow-up of patients with CHB and the selection of candidates for timely initiation of antiviral therapy that can reduce the chance of poor disease outcomes.
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About the authors
G. M Kozhevnikova
Peoples' Friendship University of Russia
Email: rudn-inf@yandex.ru
S. L Voznesensky
Peoples' Friendship University of Russia
Email: serriba@rambler.ru
O. S Efremova
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare
Email: ks517@yandex.ru
V. P Chulanov
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare
Email: vladimir.chulanov@pcr.ru
S. V Smetanina
Infectious Diseases Clinical Hospital Two, Moscow Healthcare DepartmentReferences
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