PREVENTION OF VERTICAL HIV TRANSMISSION
- Authors: SHULDYAKOV AA1, RAMAZANOVA KK.2, SOFYINA AV1
-
Affiliations:
- V.I. Razumovsky Saratov State Medical University, Ministry of Health of Russia
- Saratov Regional Center for AIDS Prevention and Control
- Issue: No 4 (2015)
- Pages: 65-69
- Section: Articles
- URL: https://journals.eco-vector.com/2226-6976/article/view/278304
- ID: 278304
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Abstract
There has been recently an increase in the number of HIV-infected people among pregnant women, which necessitates the optimization of approaches to chemoprevention (CP) of vertical HIV transmission.
Objective. To evaluate the efficiency of different routes of vertical HIV transmission.
Methods. A total of 1355 cases born to HIV-infected women registered in the Saratov Regional Center for AIDS Prevention and Control were retrospectively analyzed; and the women were divided into groups according to the mode of pregnancy management.
Results. As compared to emergency CP and no prophylaxis, a three-stage CP procedure using a few agents, which ensures a significant reduction in the risk of vertical HIV transmission to 3.1%, is a priority. The findings are supported by the clinical examples of the efficiency of current prevention and treatment regimens in HIV-infected pregnant women. Conclusion. Pregnancy is an absolute indication for CP and continued antiretroviral therapy in HIV-positive women; however, it is necessary to weight the risks and benefits when choosing a specific regimen.
Objective. To evaluate the efficiency of different routes of vertical HIV transmission.
Methods. A total of 1355 cases born to HIV-infected women registered in the Saratov Regional Center for AIDS Prevention and Control were retrospectively analyzed; and the women were divided into groups according to the mode of pregnancy management.
Results. As compared to emergency CP and no prophylaxis, a three-stage CP procedure using a few agents, which ensures a significant reduction in the risk of vertical HIV transmission to 3.1%, is a priority. The findings are supported by the clinical examples of the efficiency of current prevention and treatment regimens in HIV-infected pregnant women. Conclusion. Pregnancy is an absolute indication for CP and continued antiretroviral therapy in HIV-positive women; however, it is necessary to weight the risks and benefits when choosing a specific regimen.
About the authors
A A SHULDYAKOV
V.I. Razumovsky Saratov State Medical University, Ministry of Health of Russia
Email: Shuldaykov@mail.ru <mailto:Shuldaykov@mail.ru>
V.I. Razumovsky Saratov State Medical University, Ministry of Health of Russia
K KH RAMAZANOVA
Saratov Regional Center for AIDS Prevention and ControlSaratov Regional Center for AIDS Prevention and Control
A V SOFYINA
V.I. Razumovsky Saratov State Medical University, Ministry of Health of Russia
Email: Dr.Sofy@yandex.ru <mailto:Dr.Sofy@yandex.ru>
V.I. Razumovsky Saratov State Medical University, Ministry of Health of Russia
References
- Соколова Е.В., Покровский В.В., Деткова Н.В. Профилактика вертикальной передачи ВИЧ-инфекции в России. Эпидемиол. и инфекц. бол. 2004; 1: 20-24.
- Шульдяков А.А., Зайцева И.А., Докучаева С.Е., Турищева М.А. Гематологические особенности детей, рожденных от ВИЧ-инфицированных женщин, получавших трехэтапную профилактику вертикальной трансмиссии вируса иммунодефицита человека. Материалы III Ежегодного Всероссийского Конгресса по инфекционным болезням. М., 2011; 369.
- Соколова Е.В., Покровский В.В. Эффективность профилактических мероприятий в пресечении вертикального пути передачи ВИЧ-инфекции. Эпидемиология и вакцинопрофилактика 2003; 5: 29-31.
- Соколова Е.В., Покровский В.В. Информированность женщин и акушеров-гинекологов о профилактике вертикальной передачи ВИЧ-инфекции. Эпидемиология и вакцинопрофилактика 2003; 4: 41-44.
- Бартлетт Дж., Редфилд Р., Фам П., Мазус А.И. Клинические аспекты ВИЧ-инфекции. М.: Р. Валент, 2013. 490 с. 6.
- Профилактика передачи ВИЧ от матери к ребёнку. Оптимизация клинической тактики и эффективные методы ликвидации новых случаев ВИЧ-инфекции у детей. Клинический протокол для Европейского региона ВОЗ (обновленная версия 2012 г.). <http://www.consultant.ru/> document/cons_doc_LAW_12764
- Кулаков В.И., Баранов И.И. ВИЧ: профилактика передачи от матери к ребенку. М.: ВЕДИ, 2003; 86-93.
- Рахманова А.Г. ВИЧ/СПИД и дети. СПб: АБТ, 2007: 135-142.
- Ammann A.K. Setting goals for reducing HIV transmission from mother to infants. Conference on global strategies for the prevention of HIV transmission from mother to infants. September 3-7, 1997. Washington: DC, 1997; 10-12.
- Афонина Л.Ю., Воронин Е.Е., Фомин Ю.А., Юрин О.Г., Козырина Н.В., Покровский В.В., Конов Д.С. Клинические рекомендации по профилактике ВИЧ-инфекции от матери ребёнку (рабочий документ). М., 2009. 52 с.
- Симовьян Э. Н., Денисенко В. Б., Бекетова Е. В., Колодяжная Н. М. ВИЧ-инфекция у детей. Ростов-на-Дону: Феникс, 2010; 196-206.
- Щербинская А.М. Репродуктивное здоровье ВИЧ-позитивных женщин и девушек. Киев: День печати, 2008. 147 с. 13.
- Division on AIDS. NIH. Zidovudin for the prevention of HIV transmission from mother to infant. MMWR 1994; 343(8909): 285-288.
- Newell M.L. Vertical transmission of HIV-1: maternal immune status and obstetric factors: The European Collaboration Study. AIDS 1996; 10: 1675-1681.
- Steihm E.R. Newborn factors in material-infant transmission of pediatric HIV infection. J. Nutr.1996; 126: 2632-2636.
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