Can colitis be in rotavirus infection?
- Authors: Ploskireva A.A1, Gorelov A.V1
-
Affiliations:
- Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare
- Issue: No 2 (2016)
- Pages: 30-34
- Section: Articles
- URL: https://journals.eco-vector.com/2226-6976/article/view/278410
- ID: 278410
Cite item
Open Access
Access granted
Abstract
Objective. To analyze the possible pathogenetic mechanisms of large intestinal lesion in children with rotavirus infection. Subjects and methods. A total of 460 pediatric patients with verified monoetiologic rotavirus infection were followed up; acute infectious gastroenterocolitis (AIGEC) was recorded in 12 (2.6 ± 0.7%) children of them; this was accompanied by hemocolitis in 1 (0.2 ± 0.2%) child. Every day clinical data were assessed in all the patients; clinical laboratory examination (fecal bacteriological test, fecal rotavirus antigen enzyme immunoassay, and PCR diagnosis) was performed. Results. Antibiotics were used in the patients with AIGEC significantly more frequently (by more than 5 times) prior to admission to hospital. Antibiotic therapy preceding acute enteric infections was ascertained to be the most significant risk factor for large intestinal lesion: it increased the incidence of AIGEC by 16.7-fold in rotavirus infection. Correspondingly, the chances of large intestinal lesion were 25.9 times higher (odds ratio) in these patients than in the comparison group. This factor is characterized by high specificity (0.84) and sensitivity (0.83) as to the cause-effect relation to large intestinal lesion. Conclusion. The key factor in the pathogenesis of colitis has been established to be the development of the disease in the presence of antibiotic-associated diarrhea.
Full Text
About the authors
A. A Ploskireva
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare
Email: antonina@ploskireva.com
A. V Gorelov
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare
Email: crie@pcr.ru
References
- Сведения об инфекционных и паразитарных заболеваниях (форма 1) за январь-июнь 2015. http://www.rospotrebnadzor.ru/ activities/statistical-materials/statictic_details.php?ELEMENT_ ID=3919 просмотрено 10.12.2015.
- Подколзин А.Т. Эпидемиологическая и клиническая характеристика острых кишечных инфекций вирусной этиологии в российской федерации. Автореф. дис.. д-ра мед. наук. М., 2015.
- Parashar U.D., Gibson C.J., Bresse J.S., Glass R.I. Rotavirus and severe childhood diarrhoea. Emerg. Infect. Dis. 2006; 12: 304-306.
- Брико Н.И., Битиева Е.А., Горелов А.В., Горелова Е.А., Кудрявцев В.В., Миндлина А.Я. Эпидемиология, клиника, лечение и иммунопрофилактика ротавирусной инфекции. М., 2015. 137 с.
- Горелов А.В., Усенко Д.В. Ротавирусная инфекция у детей. Вопросы современной педиатрии 2008; 7(6): 78-84.
- Покровский В.И., Пак С.Г., Брико Н.И., Данилкин Б.К. Инфекционные болезни и эпидемиология. Учебник. 2-е изд. М.: ГЭОТАР-Медиа, 2007. 816 с.
- Михайлова Е.В., Шульдяков А.А., Кошкин А.П., Левин Д.Ю. Ротавирусная инфекция у детей. Учебное пособие. Саратов: Издательство Саратовского медицинского университета, 2006. 80 с.
- Hashavya S., Wilscrhanski M., Averbuch D., Arbell D., Pappo O., Shteyer E. Rotavirus-associated colitis in a six-month-old baby. Pediatr. Int. 2010; 52(4): p. e204-e206. doi: 10.1111/j.1442-200X.2010.03123.x
- Fernbach S.K., Lloyd-Still J.D. The radiographic findings in severe rotavirus-induced colitis. J. Can. Assoc. Radiol. 1984; 35(2): 192-194.
- Гречуха Т.А., Галицкая М.Г., Гайворонская А.Г., Намазова-Баранова Л.С. Ротавирусная инфекция. Как действительно защитить детей от тяжелых гастроэнтеритов? Педиатрическая фармакология 2013; 10(5): 14-17.
- Bendall R.P., Gray J.J. Haemorrhagic colitis and haemolytic-uraemic syndrome: false positive reaction with a rotavirus latex agglutination test. J. Clin. Pathol. 1991; 44(7): 609-610.
- Горелов А.В., Плоскирева А.А., Плоскирев А.Е., Горелова Е.А. Способ оценки степени тяжести острых кишечных инфекций у детей. Патент РФ № 2525050, 2014.
- Горелов А.В., Усенко Д.В., Тхакушинова Н.Х. Современные принципы лечения ротавирусной инфекции у детей дошкольного возраста. Эффективная фармакотерапия 2012; 6: 50-54.
- Горелов А.В., Плоскирева А.А., Руженцова Т.А. Острые кишечные инфекции в таблицах и схемах. М.: Архивь внутренней медицины, 2014. 37 с.
- Петри А., Сэбин К. Наглядная статистика в медицине. Пер. с англ. под ред. В.П. Леонова. М.: ГЭОТАР-Медиа, 2003. 144 с.
Supplementary files
