Features of the hemostatic system in liver cirrhosis of various origins
- Authors: Bilalova A.R1, Makashova V.V2,3, Aleshina O.S2, Astrina N.I2, Shabalina S.V2, Omarova K.G2
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Affiliations:
- Kazan State Medical Academy, Ministry of Health of Russia
- Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare
- Clinical Infectious Diseases Hospital Two, Moscow Healthcare Department
- Issue: No 5 (2016)
- Pages: 60-64
- Section: Articles
- URL: https://journals.eco-vector.com/2226-6976/article/view/278514
- ID: 278514
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Abstract
Objective. To provide comparative characteristics of hemostatic system indicators in patients with Child-Pugh Class B alcoholic liver cirrhosis (ALC) and mixed alcoholic liver cirrhosis (MALC) (hepatitis C + alcohol). Subjects and methods. Twenty-six patients with liver cirrhosis (LC) of different etiologies, whose hemostatic system was evaluated over time, were examined. Results. International normalized ratio (INR) and thrombin time were estimated to be significantly above normal throughout the treatment only for MALC. The activity of von Willebrand factor (vWF) was observed to be significantly above normal throughout the hospital stay and did not depend on the etiology of LC. In the outcome of ALC and MALC, the values of erythrocyte aggregation (EA) and platelet aggregation (PA) were noted to be significantly below the control ones throughout the treatment. The initial level of D-dimers in MALC was recorded to be significantly higher than both the control values and parameters in patients with ALC. Conclusion. In the patients with Child-Pugh class B liver cirrhosis, INR, thrombin time, and vWF activity were significantly higher in MALC than those in ALC, which is suggestive of an earlier and notable impairment in the hemostatic system in MALC due to the presence of two damaging factors.
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About the authors
A. R Bilalova
Kazan State Medical Academy, Ministry of Health of Russia
Email: alisa-bilalova@mail.ru
V. V Makashova
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare; Clinical Infectious Diseases Hospital Two, Moscow Healthcare Department
Email: veramakashova@yandex.ru
O. S Aleshina
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare
Email: nina_aleshina@list.ru
N. I Astrina
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare
Email: o.astrina@mail.ru
S. V Shabalina
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare
Email: nex@pcr.ru
Kh. G Omarova
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare
References
- Дядык А.И., Багрий А.Э., Вишнивецкий И.И. Цирроз печени. Новости медицины и фармации 2013; (5): 24-31.
- Майер К.П. Гепатит и последствия гепатита. Практическое руководство. М.: ГЭОТАР-Медиа, 2004. 718 с.
- Мицура В.М. HCV-ассоциированный цирроз печени: клинические проявления и причины неблагоприятных исходов. Клиническая инфектология и паразитология 2013; (3): 75-82.
- Радченко В.Г., Шабров А.В., Зиновьева Е.Н. Основы клинической гепатологии. Заболевания печени и билиарной системы. СПб.: Диалект, 2005. 864 с.
- Яковенко А.В. Цирроз печени: вопросы терапии. Consilium Medicum 2006; (7): 13-17.
- Белякин С.А., Бобров Н.А., С.В. Плюснин. Уровень потребления алкоголя населением и смертность, обусловленная циррозами печени. Как они связаны? Клинические перспективы гастроэнтерологии, гепатологии 2009; (5): 3-9.
- Попова И.В., Лопаткина Т.Н., Танащук Е.Л., Сюткин В.Е. Оценка выживаемости и риска развития гепатоцеллюлярной карциномы у больных циррозом печени сочетанной (вирусной, алкогольной) этиологии. Тер. архив 2002; (2): 44-46.
- Хазанов А.И. Современные проблемы вирусных и алкогольных болезней печени. Рос. журн. гастроэнтерол., гепатол., колопроктол. 2002; (2): 6-13.
- Khan M.H., Thomas L., Byth K., Kench J., Weltman M., George J., Liddle C., Farrell G.C. How much does alcohol. Contribute to the variabilyti of hepatic fibrosis in chronic hepatitis C? J. Gastroenterol. Hepatol. 1998; (4): 419-426.
- Poynard T., Bedossa P., Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. Lancet 1997; (9055): 1457-1462.
- Первушин Ю.В., Рогова С.Ш., Ковалевич Н.И. Лабораторные методы исследования системы гемостаза и диагностика нарушений гемокоагуляции. Учебное пособие. Ставрополь-М.: Москва, 2009. 60 с.
- Серов Н.А. Нарушение системы гемостаза у больных хроническими диффузными заболеваниями печени и пути их медикаментозной коррекции. Автореф. дис.. канд. мед. наук. Челябинск, 1989.
- Northup P.G. Hypercoagulation in liver disease. Clin. Liver Dis. 2009; (1): 109-116.
- Nagamine T., Ohtuka T., Takehara K., Arai T., Takagi H., Mori M. Thrombocytopenia associated with hepatitis C viral infection. J. Hepatol. 1996; (24): 135-139.
- Жиров И.В., Огурцов П.П. Свертывающая система крови и алкоголь. Вопросы наркологии 2001; (1): 54-59.
- Fletcher N.F., Wilson G.K., Murray J., Hu K., Lewis A., Reynolds G.M., Stamataki Z., Meredith L.W., Rowe I.A., Luo G., Lopez-Ramirez M.A., Baumert T.F., Weksler B., Couraud P.O., Kim K.S., Romero I.A., Jopling C., Morgello S., Balfe P., McKeating J.A. Hepatitis C virus infects the endothelial cells of the blood-brain barrier. Gastroenterology 2012; (142): 634-643. doi /org/10.1053/j.gastro.2011.11.028
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