THE EPIDEMIOLOGICAL AND IMMUNOLOGICAL EFFICIENCY OF USE OF WIFERON GEL IN THE PREVENTION OF INFLUENZA AND OTHER ACUTE RESPIRATORY INFECTIONS IN ORGANIZED MILITARY COLLECTIVE BODIES


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Abstract

Influenza and other acute respiratory infections (API) are 35-50% in the structure of overall morbidity among armed forces personnel. The problem of API is particular urgent for military collective bodies at high risk for respiratory tract infections. The application ofwiferon gel for their prevention allows a substantial reduction in the incidence of ARTin the organized military collective bodies (epidemiological efficacy coefficient, 50,2%; efficacy index, 2,0). The military men using this agent also showed 2.1- and 2. 4-fold reductions in the incidence of bronchitis and community- acquired pneumonias, respectively. Wiferon gel was found to have an immunomodulatory effect on the interferon (IFN) system, as confirmed by a statistically significant rise in the peripheral blood cell-induced production of IFN-a in vitro, and on cellular and humoral immunity, by contributing to the increase of total nonspecific resistance to API. The agent is well tolerated, without causing adverse or allergic reactions, and may be recommended for wide use to prevent ARI and their complications in the organized military collective bodies. It is the most expedient to apply the agent for preventive purposes when military units are formed.

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About the authors

V. G AKIMKIN

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare, Moscow; I.M. Sechenov First Moscow State Medical University

Email: vgakimkin@yandex.ru

S. I KOROTCHENKO

L.A. Tarasevich State Research Institute for Standardization and Control of Medical Biological Preparations

V. A SHEVTSOV

L.A. Tarasevich State Research Institute for Standardization and Control of Medical Biological Preparations

A. R VOLGIN

L.A. Tarasevich State Research Institute for Standardization and Control of Medical Biological Preparations

Т. А SALMINA

L. Yu KALABUKHOVA

V. V MALINOVSKAYA

N.F. Gamaleya Research Institute for Fpidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow

R. Z GATICH

OOO «FFRON», Moscow

ТА. A SEMENENKO

T. S GUSEVA

N.F. Gamaleya Research Institute for Fpidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow

O. Vasil'evna V PARSHINA

N.F. Gamaleya Research Institute for Fpidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow

E. V DMITRIYEVA

OOO «FFRON», Moscow

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