VARICELLA AND HERPES ZOSTER: MORBIDITY AND CLINICAL MANIFESTATIONS


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Abstract

The review systematizes data on the pathogenesis and clinical manifestations of primary Varicella-zoster virus (VZV) infection due to virus reactivation. It considers the course of varicella in pregnant women and neonatal infants and summarizes data on the neurologic, ophthalmologic, and visceral complications of these infections. Particular emphasis is laid on the epidemiology and pathogenesis of a severe complication of VZV infection, such as VZV vasculopathy. In addition to the typical forms of the infection, its occult form is mentioned in VZV reactivation without eruptions of the skin and mucous membranes, a condition is called zoster sine herpete. The subclinical form of infection in VZV reactivation is first reported in the Russian-language literature.

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V. F LAVROV

I.I. Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences, Moscow

Email: mech.inst@mail.ru

A. S KAZANOVA

I.I. Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences, Moscow

S. N KUZIN

I.I. Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences, Moscow

D. V DUBODELOV

I.I. Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences, Moscow

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