Efficiency of antiviral therapy for chronic hepatitis c in patients with undifferentiated connective tissue dysplasia
- Authors: Orlova S.N1, Baskhanova M.V1,2
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Affiliations:
- Ivanovo State Medical Academy, Ministry of Health of Russia
- Republican Clinical Center of Communicable Diseases
- Issue: Vol 9, No 2 (2019)
- Pages: 61-67
- Section: Articles
- URL: https://journals.eco-vector.com/2226-6976/article/view/287327
- DOI: https://doi.org/10.18565/epidem.2019.9.2.61-7
- ID: 287327
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Abstract
Objective. To determine the impact of undifferentiated connective tissue dysplasia (UCTD) on the efficiency of antiviral therapy (AVT) in patients with chronic hepatitis C (CHC). Subjects and methods. The investigation enrolled 71 patients receiving AVT for CHC, who were divided into 2 groups: 1) 48patients with signs of UCTD; 2) 23 patients without UCTD. Results. During dual AVT, a sustained virological response (SVR) was achieved in 75 and 91.3% in Groups 1 and 2, respectively. Patients with genotype 1 were recorded to have SVR in 64% cases in Group 1 and in 84.6% in Group 2. In patients with HCV genotypes 2 and 3, the achievement of SVR was even higher: in 86.9 and 100% of cases in Groups 1 and 2, respectively. Conclusion. The efficiency of AVT for CHC is associated with the presence of dysplastic manifestations in the patient. Dual AVT leads to SVR in 87% of the patients with chronic hepatitis C caused by HCV genotypes 2 and 3 and by UCTD and in 64% of those who have HCV genotype 1. There is 100% SVR in non- UCTD patients with HCV caused by HCV genotypes 2 and 85% SVR in those with HCV genotype 1. The presence of UCTD substantially affects the frequency and severity of adverse events occurring during AVT.
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About the authors
S. N Orlova
Ivanovo State Medical Academy, Ministry of Health of Russia
Email: orloff3.dok@mail.ru
Postgraduate Student, Department of Infectious Diseases, Epidemiology and Dermatovenereology Ivanovo, Russia
M. V Baskhanova
Ivanovo State Medical Academy, Ministry of Health of Russia; Republican Clinical Center of Communicable Diseases
Email: marh.74@mail.ru
Postgraduate Student, Department of Infectious Diseases, Epidemiology and Dermatovenereology Ivanovo, Russia; Groznyi, Russia
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