Mucosal changes in the upper gastrointestinal tract in patients with hemorrhagic fever with renal syndrome and leptospirosis

Objective. To study the incidence of erosive and ulcerative diseases in the gastroduodenal mucosa in patients with hemorrhagic fever with renal syndrome (HFRS) and leptospirosis. Subjects and methods. Examinations were made in 126 men and women aged 15 to 78years who were divided into 3groups: 1) 65 patients with HFRS; 2) 29 patients with leptospirosis; 3) 32patients with urinary tract infection (UTI) of unspecified etiology. Results. There was a high rate of registration of erosions and ulcers in the gastrointestinal tract (GIT) mucosa, which were interrelated to leading laboratory parameters and the severity of the underlying disease, the basis for which is deep microcirculatory disorders. Two variants of the course of GIT diseases were identified in relation to dyspepsia syndrome. There was an association of erosive and ulcerative lesions with Helicobacter pylori infection. Conclusion. Patients with HFRS and leptospirosis show a high frequency of gastroduodenal erosions and ulcers that are more commonly recorded in the severe course of the disease on its days 2-17. Helicobacter pylori infection was detected in 39% of patients with gastroduodenal mucosal erosions and ulcers. Erosive-ulcerative diseases equally frequently occurred in the presence and absence of dyspepsia syndrome. Morphological changes were characterized by microcirculatory disorders due to microvascular changes.

hemorrhagic fever with renal syndrome, leptospirosis, endoscopy, erosive and ulcerative diseases in the gastrointestinal tract