PREVALENCE OF HIGH-RISK HUMAN PAPILLOMAVIRUS ACCORDING TO THE RESULTS OF ANAL SCREENING IN MEN STRATIFIED BY THEIR SEXUAL BEHAVIOR AND HIV STATUS


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Abstract

Objective. To study the prevalence of high-risk human papillomavirus (hrHPV) in HIV-negative and HIV-positive men stratified by sexual behavior. Subjects and methods. Examinations were made in 256 male residents of Moscow and the Moscow Region who had different HIV statuses and sexual behavior. A real-time PCR assay was used to detect hrHPV in the anal scrapes. Results. The highest detection rate of hrHPV was recorded in HIV-positive men having sex with men (MSM) (79.5%), and the lowest rate was found in HIV-negative heterosexual men (3.4%). The intermediate place was occupied by HIV-negative MSM (54.5%) and HIV-positive heterosexual men (22.4%). In the HIV-positive MSM group, several (2 to 9) hrHPV genotypes were at once registered in 65.5% of cases, which was more often than in the other groups. Conclusion. The high detection rate of hrHPV DNA in the epithelial cells of the anal canal in men determines the need for HPV test-based anal screening to identify 14 hrHPV genotypes in all MSM, regardless of their HIV status and in all HIV-infected men, regardless of their sexual behavior.

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About the authors

Anna A. POPOVA

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: asya-med@maii.ru
Cand. Med. Sci., Senior Researcher Moscow, Russia

Elvira A. DOMONOVA

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: еlvira.domonova@pcr.ms
Cand. Bioi. Sci., Senior Researcher, Department of Moiecuiar Diagnosis and Epidemioiogy Moscow, Russia

Anastasia V. POKROVSKAYA

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: pokrovskaya_ av@mail.ru
Cand. Med. Sci., Senior Researcher Moscow, Russia

Nadezhda A. KLIMOVA

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: klimova@cmd.su
Junior Researcher, Department of Molecular Diagnosis and Epidemiology Moscow, Russia

Olga Yu. SHIPULINA

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: olga.shipulina@pcr.ms
Cand. Biol. Sci., Head, Subdivision of Molecular Diagnostic Methods, Department of Molecuiar Diagnosis and Epidemiology Moscow, Russia

Vadim V. POKROVSKY

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: pokrovsky.vad@yandex.ru
Prof., MD, Academician of the Russian Academy of Sciences; Head, НIV Department Moscow, Russia

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