Epidemiological manifestations of the outbreak of meningococcal infection caused by Neisseria meningitidis serogroup A in Novosibirsk in 2019


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Abstract

Objective. To analyze the epidemiological manifestations of the outbreak of meningococcal infection (MI) in Novosibirsk, its alleged causes, and infection prevention measures. Materials and methods. Fifty-four schedules for epidemiological examination of the focus of the infectious disease were studied. Samples taken from 20 patients were sent to the Russian Reference Center for Bacterial Meningitis (RCBM) to test their biological material. An AmpliSens9 NSH-FL kit was used to confirm MI. Serogrouping of N. meningitidis was done using an AmpliSens9 NmABCW-FL kit. Bacterial DNA of 6 strains was sequenced by the Sanger method applying reagents and equipment from the Applied Biosystems. Sequencing of 10 strains was performed using the HiSeq1500platform (Illumina, USA). Results. The total number of cases within 4 months was 62 people; most of them were labor migrants from Tajikistan. N. meningitidis serogroup A prevailed (91%). The outbreak was caused by a group of strains with the ST- 75 sequence type and the antigenic profile A: P1.5-2,10: F3-5, which had been previously detected in the Russian Federation. They caused sporadic diseases and were not the cause of outbreaks and epidemics. The immediate environment of the patients had risk factors for MI: overcrowding in the places of residence; the environment (relatives/neighbors in the same apartment) with acute respiratory viral infection (ARVI) and nasopharyngitis; congestion of population and intensified communication during religious fasting and holiday; a family history, including a patient with the general form of MI (GFMI), as well as a contact with a patient with GFMI outside the family. Routine preventive immunization in the risk group (more than 40,000people were vaccinated) could stop the outbreak. Conclusion. By taking into account the continuing increase in the incidence of MI in the country and the presence of risk factors for the outbreak of MI, the threat of a new epidemic rise in its incidence in the Russian Federation is not ruled out.

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About the authors

Maria A. Koroleva

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: korolevamaria389@gmail.com
Cand. Med. Sci., Senior Researcher, Laboratory for Epidemiology of Meningococcal Infection and Purulent Bacterial Meningitis

Maria I. Gritsay

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: maria-griz@mail.ru
Graduate Student, Laboratory for Epidemiology of Meningococcal Infection and Purulent Bacterial Meningitis

Konstantin O. Mironov

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: mironov@pcr.ru
Head, Scientific Group for Development of New Methods for Detection of Genetic Polymorphisms

E. A Yarygina

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

A. V Valdokhina

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Yuriy V. Yanushevich

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: yanushevich@cmd.su
Researcher, Laboratory of Molecular Mechanisms of Antibiotic Resistance

Yuliya G. Mikhailova

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: mihailova@cmd.su
Head, Laboratory of Molecular Mechanisms of Antibiotic Resistance

A. S Speranskaya

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Albina A. Melnikova

Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: melnikova_aa@gsen.ru
Deputy Head

Irina S. Koroleva

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: irina-korol@yandex.ru
MD, Head, Laboratory for Epidemiology of Meningococcal Infection and Purulent Bacterial Meningitis

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