The spectrum of adverse events in the treatment of multidrug-resistant tuberculosis among people receiving antiretroviral therapy
- Authors: Degtyareva S.Y.1, Zimina V.N.1,2, Pokrovskaya A.V.1,3, Konovalova A.A.4, Volchenkov G.V.5
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Affiliations:
- Peoples' Friendship University of Russia
- National Medical Research Center for Phthisiopulmonology and Infectious Diseases
- Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
- H-Clinic University Clinic
- Center for Specialized Phthisiopulmonological Care
- Issue: Vol 11, No 2 (2021)
- Pages: 100-105
- Section: Articles
- URL: https://journals.eco-vector.com/2226-6976/article/view/287754
- DOI: https://doi.org/10.18565/epidem.2021.11.2.100-5
- ID: 287754
Cite item
Open Access
Access granted
Abstract
The outcomes of treatment for multidrug-resistant tuberculosis (MDR-TB) are significantly inferior to those in the absence of M. tuberculosis resistance. The presence of HIV infection further worsens the prognosis in these patients, including due to an increase in the frequency of adverse events (AEs) of therapy. Objective. To analyze the structure of AEs in the simultaneous treatment of MDR-TB and HIV infection and to study their possible relationship to antiretroviral drugs. Subjects and methods. Design: a retrospective cohort study. The investigators studied the medical records of patients over the age of 18 who had been registered for the Fourth TB chemotherapy regimen in Vladimir and the Vladimir Region in 2014-2016 and received antiretroviral therapy (ART) at the first stage of treatment. Results. AEs of varying severity were observed in 63.3% of patients. The most often recorded cases were gastrointestinal AES (18.1%); the little less often cases were hepatotoxic and myelotoxic AEs (11.1% each). Among the patients receiving antiretroviral therapy based on protease inhibitors; AEs were significantly more common than those in the group of individuals taking non-nucleoside reverse transcriptase inhibitors. Conclusion. AES during combination therapy for MDR-TB and HIV infection were found with high frequency. Further investigations are advisable to improve the algorithms for their monitoring and prevention.
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About the authors
Svetlana Yu. Degtyareva
Peoples' Friendship University of Russia
Email: svet@mail.ru
Assistant Lecturer, Department of Infectious Diseases with Courses in Epidemiology and Phthisiology, Medical Institute
Vera N. Zimina
Peoples' Friendship University of Russia; National Medical Research Center for Phthisiopulmonology and Infectious Diseases
Email: vera-zim@yandex.ru
MD, Professor, Department of Infectious Diseases with Courses in Epidemiology and Phthisiology; Leading Researcher
Anastasia V. Pokrovskaya
Peoples' Friendship University of Russia; Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: pokrovskaya_av@mail.ru
Cand. Med. Sci., Senior Researcher; Associate Professor, Department of Infectious Diseases with Courses in Epidemiology and Phthisiology, Medical Institute
Anastasia A. Konovalova
H-Clinic University Clinic
Email: konovalova@h-clinic.ru
Infectiologist
Grigory V. Volchenkov
Center for Specialized Phthisiopulmonological Care
Email: root@tubdisp.elcom.ru
Head Doctor
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