Problems of complex use of bacteriophages for prevention and treatment


Citar

Texto integral

Acesso aberto Acesso aberto
Acesso é fechado Acesso está concedido
Acesso é fechado Acesso é pago ou somente para assinantes

Resumo

Bacteriophages are alternative medicines to overcome the problem of the global spread of multidrug- and pandrug-resistant strains to antimicrobial agents. The priority developments in the use of bacteriophages, which were made in the Soviet Union in the 1970s and 1980s, have shown their high epidemiological efficacy and prospects for using these drugs in the fight against infections. At the same time, the requirements for the biological safety of drugs and for medical care determine the need to consider a number of aspects that prevent the use of bacteriophages. The paper considers the problems that limit the use of bacteriophages in medicine.

Texto integral

Acesso é fechado

Sobre autores

Б. Brusina

Kemerovo State Medical University, Ministry of Health of Russia

Email: brusina@mail.ru
MD, Head, Department of Epidemiology 22a, Voroshilov St., Kemerovo 650056, Russia Telephone: +7(3842) 25-59-15

O. Drozdova

Kemerovo State Medical University, Ministry of Health of Russia

Email: om-drozdova@mail.ru
MD, Professor, Department of Epidemiology Kemerovo, Russia

A. Aleshkin

G.N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: andreialeshkin@googlemail.com
BD, Head, Laboratory for Clinical Microbiology and Biotechnology of Bacteriophages Moscow, Russia

D. Shagin

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Customers Rights and Human Well-Being

Email: shagdim777@gmail.com
Cand. Biol. Sci., Senior Researcher, Department for Molecular Diagnosis and Epidemiology of Bacteriophages Moscow, Russia

A. Tutelian

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Customers Rights and Human Well-Being

Email: bio-tav@yandex.ru
MD, Corresponding Member of the Russian Academy of Sciences, Head, Laboratory for Healthcare-Associated Infections Moscow, Russia

V. Akimkin

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Customers Rights and Human Well-Being

Email: vgakimkin@yandex.ru
MD, Аcademician of the Russian Academy of Sciences, Director Moscow, Russia

Bibliografia

  1. G20 Leaders’ Declaration: Shaping an interconnected world (Hamburg, 7/8 July 2017). URL: https://www.g20.org/en/g20/ timeline
  2. Алешкин А.В., Селькова E.П., Ершова О.Н., Шкода А.С., Бочкарева С.С., Митрохин С.Д., Киселева И.А., Орлова О.Е., Рубальский Е.О., Зулькарнеев Э.Р. Концепция персонализированной фаготерапии пациентов отделения реанимации и интенсивной терапии, страдающих инфекциями, связанными с оказанием медицинской помощи. Фундаментальная и клиническая медицина 2018; 3(2): 66-74. doi: 10.23946/25000764-2018-3-2-66-74
  3. Дроздова О.М., Брусина Е.Б. Применение бактериофагов в эпидемиологической практике: взгляд через столетие. Эпидемиология и инфекционные болезни 2010; (5): 20-4.
  4. Костюкевич О.И. Применение бактериофагов в клинической практике: эпоха Возрождения. РМЖ 2015; (21): 1258-62.
  5. Акимкин В.Г., Шестопалова Т.Н., Брусина Е.Б. О разработке метода биологической дезинфекции с использованием бактериофагов в очагах инфекций, связанных с оказанием медицинской помощи. Инфекционные болезни 2016; 14(S1): 315.
  6. Brusina E., Drozdova O., Zueva L., Akimkin V., Fedorova L. Complex application of bacteriophages as a method of healthcare-associated infections control. Antimicrob. Resi st. Infect. Control 2015, 4(Suppl 1): 46. URL: http://www. aricjournal.com/content/4/S1/P46
  7. Brusina E.B., Drozdova O.M., Kutikhin A.G. A new method of bacteriophage-based disinfection in healthcare settings. 2013, 2(Suppl 1): O20. URL: http://www.aricjournal.com/ content/2/S1/O20
  8. Metzker M.L. Sequencing technologies - the next generation. Nat. Rev. Genet. 2010; 11(1): 31-46. doi: 10.1038/nrg2626.
  9. Penadös J.R., Chen J., Quiles-Puchalt N., Carpena N., Novick R.P. Bacteriophage-mediated spread of bacterial virulence genes. Curr. Opin. Microbiol. 2015: 171-8. DOI: 10.1016/j. mib.2014.11.019.
  10. Modi S.R., Lee H.H., Spina C.S., Collins J.J. Antibiotic treatment expands the resistance reservoir and ecological network of the phage metagenome. Nature 2013; 499(7457): 219-22. doi: 10.1038/nature12212.
  11. Colomer-Lluch M., Jofre J., Muniesa M. Antibiotic resistance genes in the bacteriophage DNA fraction of environmental samples. PLoS One 2011; 6(3): e17549. doi: 10.1371/journal. pone.0017549.

Arquivos suplementares

Arquivos suplementares
Ação
1. JATS XML
Baixar

Este site utiliza cookies

Ao continuar usando nosso site, você concorda com o procedimento de cookies que mantêm o site funcionando normalmente.

Informação sobre cookies