New possibilities of predicting the outcomes of antiviral therapy in patients with chronic hepatitis B


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Abstract

Objective. To develop a procedure for predicting the outcomes of antiviral therapy with entecavir in HBeAg-negative patients with chronic hepatitis B (CHB). Subjects and methods. A total of 154 primary patients with HBeAg-negative CHB were examined. The diagnosis was made on the basis of clinical, epidemiological, biochemical, instrumental, serological, and molecular genetic studies. The findings were subjected to mathematical and statistical processing that included descriptive assessment, discriminant analysis, and distribution normality analysis using the x2 test and the Kolmogorov-Smirnov goodness-of-fit test. Conclusion. A discriminant model has been developed, which can predict the outcome of antiviral therapy with entecavir in patients with HBeAg-negative CHB before treatment, with the probability of an erroneous prognosis of less than 10-26, which is recommended to be used in clinical practice to treat this category of patients.

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About the authors

E. A Zaitseva

Samara State Medical University, Ministry of Health of Russia

Email: inf-samgmu@yandex.ru
Assistant Lecturer, Department of Infectious Diseases with Course of Epidemiology Samara, Russia

L. L Popova

Samara State Medical University, Ministry of Health of Russia

Email: ll.popova@mail.ru
Samara, Russia

D. Yu Konstantinov

Samara State Medical University, Ministry of Health of Russia

Email: dk.samgmu@mai
Cand. Med. Sci., Associate Professor, Department of Infectious Diseases with Course of Epidemiology 89, Chapaevskaya St., Samara 443099, Russia Telephone/fax: +7(846) 260-06-39

G. V Nedugov

Samara Regional Forensic Medical Examination Bureau

Email: nedugovh@mail.ru
Cand. Med. Sci., Head, Histology Department Samara, Russia

References

  1. Константинова Е.А. Клинико-лабораторная характеристика течения рецидива НВеAg-негативного варианта хронического гепатита В у пациентов с высоким и низким содержанием НВsAg. Аспирантский вестник Поволжья 2010; (7-8): 52-5.
  2. Lok A.S.F., McMahon B.J. Chronic hepatitis B. Hepatology 2007; 45: 507-39.
  3. Ткаченко Л.И., Малеев В.В. Санникова И.В., Пасечников В.Д., Титоренко М.В. Сравнительный анализ эффективности нуклеозидных аналогов в лечении пациентов хроническим гепатитом В. Инфекционные болезни 2012; (2): 2-7.

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