Single nucleotide polymorphisms in Toll-like receptor genes associated with the risk of tuberculosis and other diseases of the lower respiratory tract

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Abstract

The Toll-like receptor (TLR) family plays important roles in pathogen recognition and control and regulation of inflammation. Single nucleotide polymorphisms (SNPs) in TLR genes can disrupt the functioning of certain signaling pathways, which increases the risk of infectious diseases and may lead to an increased risk of complications of other bronchopulmonary pathologies. A review of studies on the association of SNPs in TLR genes with lower respiratory tract diseases, conducted in accordance with the PRISMA-ScR protocol, is presented. The extent of studies conducted, the representation of subpopulations and geographic regions, as well as risk factors and the severity of infectious diseases in carriers of risk alleles were assessed.

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About the authors

Svetlana A. Salamaikina

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; Moscow Institute of Physics and Technology

Author for correspondence.
Email: salamaykina@cmd.su
ORCID iD: 0000-0002-2517-5048

Researcher, Laboratory of Molecular Methods for Studying Genetic Polymorphisms, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; Postgraduate Student, Moscow Institute of Physics and Technology (MIPT)

Russian Federation, Moscow; Moscow

Konstantin O. Mironov

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: mironov@pcr.ru
ORCID iD: 0000-0001-8207-9215

MD, Head, Laboratory of Molecular Methods for Studying Genetic Polymorphisms

Russian Federation, Moscow

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