Correlation assessment of the relationship between selenium levels and some indicators of oxidative stress in the blood serum in patients with tick-borne rickettsiosis in the south of the khabarovsk territory

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Objective. Evaluation of the relationship between selenium (Se) levels and oxidative status in patients with tick-borne rickettsiosis (TBR) caused by R. heilongjiangensis to understand the pathogenesis, assess the severity and possible prognosis of the disease.

Materials and methods. The Se levels and some chemiluminescence indicators in patients with a moderate form of TBR were analyzed.

Results. It was found that the mean blood serum Se level of the examined patients at the height of the disease was statistically significantly reduced, which was combined with a significant initiation of free radical oxidation processes and a sharp suppression of the mobilization of antioxidant antiradical defense. During the period of convalescence in patients with TBR, despite the extinction of the main clinical manifestations of the disease, the activity of free radical oxidation processes continued to increase. Correlation analysis revealed a reliable moderate negative relationship between the chemiluminescent parameters of short-lived reactive oxygen species and the blood serum Se level.

Conclusion. The data obtained indicate the conjugation of the processes of selenium and oxidative status. Se deficiency is reflected in a decrease in the activity of antioxidant antiradical defense.

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作者简介

Evgenia Mokretsova

Far Eastern State Medical University, Ministry of Health of Russia

编辑信件的主要联系方式.
Email: bremer68@mail.ru
ORCID iD: 0000-0001-9492-2660

Cand. Med. Sci., Associate Professor, Department of Infectious Diseases and Epidemiology

俄罗斯联邦, Khabarovsk

Gennady Tomilka

Far Eastern State Medical University, Ministry of Health of Russia

Email: genntom@mail.fesmu.ru
ORCID iD: 0000-0002-8785-2147

Professor, MD, Head, Department of Infectious Diseases and Epidemiology

俄罗斯联邦, Khabarovsk

Yuri Kovalsky

Far Eastern State Medical University, Ministry of Health of Russia

Email: kovalyura@mail.ru
ORCID iD: 0000-0001-7433-6285

Professor, MD, Head, Department of Biological Chemistry and Clinical Laboratory Diagnostics

俄罗斯联邦, Khabarovsk

Natalya Yakusheva

Far Eastern State Medical University, Ministry of Health of Russia

Email: whiteout@mail.ru
ORCID iD: 0000-0003-1561-5465

Cand. Pharm. Sci., Associate Professor, Department of Pharmacy and Pharmacology

俄罗斯联邦, Khabarovsk

Alexander Shchupak

Far Eastern State Medical University, Ministry of Health of Russia

Email: schupakalex@mail.ru
ORCID iD: 0000-0001-6255-7638

Cand. Med. Sci., Associate Professor, Head, Department of Clinical Toxicology and Extreme Medicine

俄罗斯联邦, Khabarovsk

Viktor Maleev

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: maleyev@pcr.ru
ORCID iD: 0000-0001-5748-178X

Professor, Academician of the Russian Аcademy of Sciences, MD,, Advisor to the Director for Scientific Work

俄罗斯联邦, Moscow

参考

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2. Figure. Se level in patients with TBR in the dynamics of the disease Reliability of differences in indicators between groups: р1-2 – 1st and 2end; p1-3 - 1st and 3rd; р2-3 – 2end и 3rd.

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