Diversity of streptococcus species isolated in the departments of purulent surgery and coloproctology of a multidisciplinary hospital and their antibiotic resistance

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Abstract

Objective. Determination of the frequency of occurrence and characteristics of sensitivity to antibiotics of different Streptococcus species isolated from patients in the departments of purulent surgery and coloproctology of a multidisciplinary hospital in Moscow.

Materials and methods. An epidemiological observational descriptive continuous retrospective study using data from patients of departments of purulent surgery (n = 2094) and coloproctology (n = 1933) aged 18 years and older for 2017–2022 was conducted. The sensitivity to antibiotics of 1208 streptococcal cultures isolated in the department of purulent surgery and 827 cultures obtained in the department of coloproctology was analyzed. Antibiotic susceptibility was determined using microbiological analyzers BD Phoenix M50 and VITEK 2XL in accordance with EUCAST and CLSI recommendations.

Results. In the department of purulent surgery, Streptococcus pyogenes (28,53%), Streptococcus agalactiae (22,0%), Streptococcus anginosus (16,49%) were isolated statistically significantly more often; in the department of coloproctology – S. anginosus (41,66%), Streptococcus constellatus (15,99%), S. agalactiae (14,54%). A significant proportion of S. agalactiae cultures showed resistance to tetracycline (80,32%) and clindamycin (41,13%). In the department of purulent surgery, S. agalactiae resistance to erythromycin increased from 15,4 to 38,3% from 2019 to 2021, in the department of coloproctology – from 16,67 to 38,46%.

Conclusion. The results obtained revealed significant differences in the antimicrobial resistance of streptococci and showed the inappropriateness of using tetracycline and erythromycin to treat patients in the department of purulent surgery.

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About the authors

Azamat O. Kaytukov

Sechenov University

Author for correspondence.
Email: dodta1510@mail.ru
ORCID iD: 0000-0003-4399-081X

Postgraduate Student, Epidemiology and Evidence-Based Medicine Department

Russian Federation, Moscow

Ekaterina V. Glushkova

Sechenov University

Email: glushkova_e_v@staff.sechenov.ru
ORCID iD: 0000-0001-6997-7598

Cand. Med.Sci., Associate Professor, Epidemiology and Evidence-Based Medicine Department

Russian Federation, Moscow

Elizaveta A. Dyment

Sechenov University

Email: elizavetadyment@mail.ru
ORCID iD: 0009-0001-1048-5844

6th year Student at the Medical and Preventive Faculty

Russian Federation, Moscow

Tatiana A. Salmina

L.A. Vorokhobova City Clinical Hospital № 67 of the Moscow Healthcare Department

Email: sta_1172@mail.ru

Head, Epidemiology Department

Russian Federation, Moscow

Vasiliу G. Kryzhanovskу

L.A. Vorokhobova City Clinical Hospital № 67 of the Moscow Healthcare Department

Email: kryzhanv@yandex.ru

Deputy Chief Physician for Sanitary and Epidemiological Issues

Russian Federation, Moscow

Olga E. Orlova

L.A. Vorokhobova City Clinical Hospital № 67 of the Moscow Healthcare Department

Email: o.e.orlova@yandex.ru
ORCID iD: 0000-0001-7210-1116

Cand. Biol. Sci., Head, Microbiological Laboratory

Russian Federation, Moscow

Nikolay I. Briko

Sechenov University

Email: nbrico@mail.ru
ORCID iD: 0000-0002-6446-2744

Professor, Academician, Russian Academy of Sciences, MD, Head, Department of Epidemiology and Evidence-Based Medicine, Director

Russian Federation, Moscow

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2. Fig 1. Frequency of isolation of the predominant microorganisms in patients of City Clinical Hospital № 67 (per 100 hospitalized) а – department of purulent surgery; b – department of coloproctology.

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3. Fig 2. The proportion of commonly occurring streptococci isolated from patients of City Clinical Hospital № 67 in 2017-2022 а – department of purulent surgery; b – department of coloproctology.

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4. Fig 3. Structure of microorganisms isolated in association with streptococci from patients of City Clinical Hospital № 67 in 2017-2022 а – department of purulent surgery; b – department of coloproctology.

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