The use of integrative indicators based on laboratory data to assess the efficiency of the current epidemiological surveillance system
- Authors: Dubodelov D.V.1, Akimkin V.G.1, Semenenko T.A.2, Esman A.S.1, Kuzin S.N.1, Ugleva S.V.1, Voronin E.M.1, Gerasimov A.N.1, Cherkashina A.S.1, Khafizov K.F.1, Sycheva N.V.1, Korabelnikova M.I.1, Monakhova A.A.1, Beregovykh R.M.1
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Affiliations:
- Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
- N.F. Gamaleya National Research Center for Epidemiology and Microbiology
- Issue: Vol 15, No 1 (2025)
- Pages: 35-42
- Section: Original Investigations
- URL: https://journals.eco-vector.com/2226-6976/article/view/684505
- DOI: https://doi.org/10.18565/epidem.2025.15.1.35-42
- ID: 684505
Cite item
Abstract
Objective. Evaluation of the prospects for using integrative indicators based on laboratory data to analyze the completeness and objectivity of morbidity data, as well as comparative and operational assessment of the effectiveness of the epidemiological surveillance system for the new coronavirus infection (COVID-19).
Materials and methods. The calculation and analysis of integrative indicators was carried out based on the results of PCR studies for the presence of SARS-CoV-2 RNA according to the SOLAR (System of Laboratory Aggregation Result) platform and information on the incidence of COVID-19 in the constituent entities of the Russian Federation for the period 2022–2023.
Results. It is shown that the results of PCR studies can be used to assess the dynamics of the epidemic process. Methods for assessing the completeness and objectivity of morbidity data in the constituent entities of the Russian Federation using integrative indicators are proposed. The use of integrative indicators to identify regional characteristics in the diagnosis and recording of COVID-19 cases is substantiated.
Conclusion. Integrative indicators based on morbidity data and laboratory data can be successfully used as criteria for assessing the completeness and objectivity of information in epidemiological analysis. They can also serve as a basis for comparative and operational assessment of the effectiveness of the epidemiological surveillance system.
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About the authors
Dmitriy V. Dubodelov
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Author for correspondence.
Email: dubodelov@cmd.su
ORCID iD: 0000-0003-3093-5731
Сand. Med. Sci., Senior Researcher, Laboratory of Viral Hepatitis
Russian Federation, MoscowVasily G. Akimkin
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: crie@pcr.su
ORCID iD: 0000-0003-4228-9044
Professor, Academician of the Russian Academy of Sciences, MD, Director
Russian Federation, MoscowTatiana A. Semenenko
N.F. Gamaleya National Research Center for Epidemiology and Microbiology
Email: semenenko@gamaleya.org
ORCID iD: 0000-0002-6686-9011
Professor, MD, Head, Epidemiology Department; Рrofessor, Department of Infectology and Virology, Institute of Professional Education
Russian Federation, MoscowAnna S. Esman
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: esman@cmd.su
ORCID iD: 0000-0002-5456-7649
Researcher, Laboratory of Molecular Methods for Studying of Genetic Polymorphisms
Russian Federation, MoscowStanislav N. Kuzin
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: kuzin@cmd.su
ORCID iD: 0000-0002-0616-9777
Professor, MD, Head, Laboratory of Viral Hepatitis
Russian Federation, MoscowSvetlana V. Ugleva
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: ugleva@cmd.su
ORCID iD: 0000-0002-1322-0155
MD, Associate Professor, Head, Scientific and Analytical Department
Russian Federation, MoscowEvgeniy M. Voronin
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: voronin@cmd.su
ORCID iD: 0000-0001-5925-7757
Cand. Med. Sci., Head, Scientific Group of Mathematical Methods and Epidemiological Forecasting
Russian Federation, MoscowAndrey N. Gerasimov
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: gerasimov.a@cmd.su
ORCID iD: 0000-0003-4549-7172
Professor, Cand. Phys. and Math. Sci, Lead Researcher, Scientific Group of Mathematical Methods and Epidemiological Forecasting
Russian Federation, MoscowAnna S. Cherkashina
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: cherkashina@pcr.ms
ORCID iD: 0000-0001-7970-7495
Cand. Chem. Sci., Director, Scientific Group of Genetic Engineering and Biotechnology
Russian Federation, MoscowKamil F. Khafizov
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: khafizov@cmd.su
ORCID iD: 0000-0001-5524-0296
Cand. Biol. Sci., Head, Laboratory of Genomic Studies
Russian Federation, MoscowNatalia V. Sycheva
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: sycheva.n@cmd.su
ORCID iD: 0000-0001-8557-6540
Junior Researcher, Laboratory of Infections Associated with the Provision of Medical Care
Russian Federation, MoscowMarina I. Korabelnikova
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: korabelnikova@cmd.su
ORCID iD: 0000-0002-2575-8569
Researcher, Laboratory of Viral Hepatitis
Russian Federation, MoscowAngelina A. Monakhova
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: monaxova.angelina@mail.ru
ORCID iD: 0009-0000-9950-2649
Postgraduate Student
Russian Federation, MoscowRoman M. Beregovykh
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: beregovykh@cmd.su
ORCID iD: 0009-0000-3956-2148
Specialist in Data Analysis and Processing
Russian Federation, MoscowReferences
- Попова А.Ю., Ежлова Е.Б., Смоленский В.Ю., Брагина И.В., Орлов М.Ю., Демина Ю.В. и др. COVID-19: научно-практические аспекты борьбы с пандемией в Российской Федерации. Саратов: ООО «Амирит», 2021. 608 с./Popova A.Yu., Ezhlova E.B., Smolenskij V.Yu., Bragina I.V., Orlov M.Yu., Demina Yu.V. et al. [COVID–19: scientific and practical aspects of combating the pandemic in the Russian Federation]. Saratov: Amirit, 2021. 608 p. (In Russ.).
- Акимкин В.Г., Семененко Т.А., Хафизов К.Ф., Углева С.В., Дубоделов Д.В., Колосовская Е.Н. Стратегия геномного эпидемиологического надзора. Проблемы и перспективы. Журнал микробиологии, эпидемиологии и иммунобиологии 2024; 101(2): 163–172. doi: 10.36233/0372-9311-507/Akimkin V.G., Semenenko T.A., Khafizov K.F., Ugleva S.V., Dubodelov D.V., Kolosovskaia E.N. [Genomic surveillance strategy. Problems and perspectives]. Journal of Microbiology, Epidemiology and Immunobiology 2024; 101(2): 163–172. (In Russ.). doi: 10.36233/0372-9311-507
- Акимкин В.Г., Семененко Т.А., Углева С.В., Дубоделов Д.В., Кузин С.Н., Яцышина С.Б. и др. COVID-19 в России: эпидемиология и молекулярно-генетический мониторинг. Вестник РАМН 2022; 77(4): 254–260. doi: 10.15690/vramn2121/Akimkin V.G., Semenenko T.A., Ugleva S.V., Dubodelov D.V., Kuzin S.N., Iatsyshina S.B. et al. [COVID-19 in Russia: epidemiology and molecular genetic monitoring]. Annals of the Russian Academy of Medical Sciences 2022; 77(4): 254–260. (In Russ.). doi: 10.15690/vramn2121
- Черкасский Б.Л. Теоретическое обоснование структуры эпидемиологического надзора. В кн.: Сб. науч. тр. «Эпидемиологический надзор за инфекционными болезнями». М. 1987: 16–22./Cherkasskу B.L. [Theoretical substantiation of the structure of epidemiological surveillance]. In: Epidemiological surveillance of infectious diseases. Moscow. 1987: 16–22. (In Russ.).
- Акимкин В.Г., Попова А.Ю., Плоскирева А.А., Углева С.В., Семененко Т.А., Пшеничная Н.Ю. и др. COVID-19: эволюция пандемии в России. Сообщение I: проявления эпидемического процесса COVID-19. Журнал микробиологии, эпидемиологии и иммунобиологии 2022; 99(3): 269–286. doi: 10.36233/0372-9311-276/ Akimkin V.G., Popova A.Y., Ploskireva A.A., Ugleva S.V., Semenenko T.A., Pshenichnaia N.Yu. et al. [COVID-19: the evolution of the pandemic in Russia. Report I: manifestations of the COVID-19 epidemic process]. Journal of Microbiology, Epidemiology and Immunobiology 2022; 99(3): 269–286. (In Russ.). doi: 10.36233/0372-9311-276
- Болотовский В.Н., Зарицкий А.М., Зуев В.А., Кашкин К.П., Кондрусев А.И., Ковалева Е.П. и др. Эпидемиологический анализ. В кн.: Покровский В.И., ред. Руководство по эпидемиологии инфекционных болезней [в 2 т.]. T.1. М.: Медицина, 1993. 464 с./ Bolotovskii V.N., Zaritskii A.M., Zuev V.A., Kashkin K.P., Kondrusev A.I., Kovaleva E.P. et al. [Epidemiological analysis]. In: Pokrovskу V.I. еd. Handbook of Epidemiology of infectious diseases [in 2 volumes]. Vol. 1. Moscow: Medicine, 1993. 464 p. (In Russ.).
- Акимкин В.Г., Хафизов К.Ф., Дубоделов Д.В., Воронин Е.М., Черкашина А.С., Углева С.В. и др. Молекулярно-генетический мониторинг и технологии цифровой трансформации в современной эпидемиологии. Вестник РАМН 2023; 78(4): 363–369. doi: 10.15690/vramn13672/ Akimkin V.G., Khafizov K.F., Dubodelov D.V., Voronin E.M., Cherkashina A.S., Ugleva S.V. et. al. [Molecular genetic monitoring and digital transformation technologies in modern epidemiology]. Annals of the Russian Academy of Medical Sciences 2023; 78(4): 363–369. (In Russ.). doi: 10.15690/vramn13672
- Virtanen P., Gommers R., Oliphant T.E., Haberland M., Reddy T., Cournapeau D. et. al. SciPy 1.0: Fundamental Algorithms for Scientific Computing in Python. Nat. Methods 2020; (17): 261–272. doi: 10.1038/s41592-019-0686-2
- The pandas development team. 2024. pandas-dev/pandas: Pandas (v2.2.2). Zenodo. doi: 10.5281/zenodo.10957263
- Seabold S., Perktold J. Statsmodels: Econometric and statistical modeling with python. 2010. Conference: Python in Science Conference. doi: 10.25080/Majora-92bf1922-011
- Профилактика инфекционных болезней. Эпидемиология и профилактика COVID-19: Методические рекомендации МР 3.1.0170-20. М.: Роспотребнадзор, 2020. [Prevention of infectious diseases. Epidemiology and prevention of COVID-19. Methodological recommendations of MP 3.1.0170-20]. Moscow, 2020. (In Russ.).
- Mei Q., Li J., Du R., Yuan X., Li M., Li J. Assessment of patients who tested positive for COVID-19 after recovery. Lancet Infect. Dis. 2020; 20(9): 1004–1005. doi: 10.1016/S1473-3099(20)30433-3
- Calba C., Goutard F.L., Hoinville L., Hendrikx P., Lindberg A., Saegerman C. et al. Surveillance systems evaluation: a systematic review of the existing approaches. BMC Public Health 2015; 15(448): 1–13. doi: 10.1186/s12889-015-1791-5
- Hendrikx P., Gay E., Chazel M., Moutou F., Danan C., Richomme C. et al. OASIS: an assessment tool of epidemiological surveillance systems in animal health and food safety. Epidemiol. Infect. 2011; 139(10): 1486–1496. doi: 10.1017/S0950268811000161
- Добролюбова Е.И., Южаков В.Н. Комплексная оценка результативности и эффективности санитарно-эпидемиологического надзора. Социум и власть 2020; 6(86): 40–54. doi: 10.22394/1996-0522-2020-6-40-54/Dobrolyubova E.I., Yuzhakov V.N. [Comprehensive assessment of the effectiveness and efficiency of sanitary and epidemiological surveillance]. Society and Рower 2020; 6(86): 40–54. (In Russ.). doi: 10.22394/1996-0522-2020-6-40-54
- Declich S., Carter A.O. Public health surveillance: historical origins, methods and evaluation. Bull. World Health Organ 1994; 72(2): 285–304.
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